Publication Name	World Journal of Psychiatry
Manuscript ID	110690
Country	China

Category	Psychiatry
Manuscript Type	Observational Study
Article Title	Cognitive impairment and pain in depression: The mediating role of the kynurenine pathway
Manuscript Source	Unsolicited Manuscript
All Author List	Ya-Jun Yun, Qi Zhang, Wen-Xuan Zhao, Ning Fan, Zhi-Ren Wang, Hui-Mei An and Fude Yang
Funding Agency and Grant Number	Funding Agency Grant Number Grants from Beijing Municipal Science and Technology Commission No. Z191100006619020 Beijing Municipal Administration of Hospitals Incubating Program, 2023 No. PX2023070 Beijing Municipal Administration of Hospitals Incubating Program, 2024 No. PX2024072
Corresponding Author	Fude Yang, Professor, . yangfd2002@163.com
Key Words	Cognition; Pain; Depression; Kynurenine; Tryptophan
Core Tip	This study explores the relationship between the tryptophan-kynurenine (TRP-KYN) pathway and cognitive function in major depressive disorder (MDD) patients with and without painful physical symptoms. By analyzing serum metabolites and clinical assessments, we found that KYN level and TRP/KYN ratio were associated with pain severity but not with cognitive performance. These findings highlight the potential dissociation between pain-related and cognitive mechanisms in MDD and underscore the need for further studies on the biopsychosocial underpinnings of depression-related cognitive dysfunction.
Citation	Yun YJ, Zhang Q, Zhao WX, Fan N, Wang ZR, An HM, Yang FD. Cognitive impairment and pain in depression: The mediating role of the kynurenine pathway. World J Psychiatry 2025; In press

Received	2025-06-13 09:50
Peer-Review Started	2025-06-13 09:50
To Make the First Decision
Return for Revision	2025-07-14 06:44
Revised	2025-07-29 02:20
Second Decision	2025-08-28 01:08
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-09-04 07:13
Articles in Press	2025-09-04 07:13
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Typeset the Manuscript

ISSN	2220-3206 (online)
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