Publication Name	World Journal of Hepatology
Manuscript ID	110698
Country	Japan

Category	Gastroenterology & Hepatology
Manuscript Type	Case Control Study
Article Title	Cytokeratin 18 fragment is associated with steatosis-associated fibrosis estimator score and lipid in patients with steatotic liver disease
Manuscript Source	Invited Manuscript
All Author List	Tatsuki Ichikawa, Satoshi Miuma, Mio Yamashima, Shinobu Yamamichi, Makiko Koike, Yusuke Nakano, Hiruyuki Yajima, Osamu Miyazaki, Tomonari Ikeda, Takauma Okamura, Naohiro Komatsu, Miruki Yoshino and Hisamitsu Miyaaki
Funding Agency and Grant Number
Corresponding Author	Tatsuki Ichikawa, MD, Department of Gastroenterology, Nagasaki Harbor Medical Center, 1-7-1 Sakamoto, Nagasaki 850-8555, Japan. ichikawa@nagasaki-u.ac.jp
Key Words	Cytokeratin 18 fragment; Steatosis-associated fibrosis estimator score; Triglyceride; High-density lipoprotein cholesterol; Steatotic liver disease
Core Tip	Serum cytokeratin 18 fragment (CK18F) has been developed as a new non-invasive test for risk assessment of steatotic liver disease (SLD). We included 125 patients who were assessed for SLD and had CK18F measured. Steatosis-associated fibrosis estimator (SAFE) score, liver stiffness (LS), and FibroScan-aspartate aminotransferase (FAST) score were compared with CK18F. CK18F was associated with aspartate aminotransferase, alanine aminotransferase, and triglycerides (TG). FAST and SAFE score were associated with high CK18F (> 260 U/L), but not fibrosis-4 and LS. The risk of high CK18F was higher when high TG and low high-density lipoprotein were combined than when each was present alone.
Citation	Ichikawa T, Miuma S, Yamashima M, Yamamichi S, Koike M, Nakano Y, Yajima H, Miyazaki O, Ikeda T, Okamura T, Komatsu N, Yoshino M, Miyaaki H. Cytokeratin 18 fragment is associated with steatosis-associated fibrosis estimator score and lipid in patients with steatotic liver disease. World J Hepatol 2025; In press

Received	2025-06-13 09:42
Peer-Review Started	2025-06-13 09:42
To Make the First Decision
Return for Revision	2025-06-26 08:07
Revised	2025-07-03 05:17
Second Decision	2025-09-25 02:39
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-09-25 09:15
Articles in Press	2025-09-25 09:15
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ISSN	1948-5182 (online)
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