Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	110704
Country	South Korea

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Stromal secreted protein acidic and rich in cysteine expression: A potential target for improved prognosis in patients with pancreatic cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Hye Yeon Yang, Jae Uk Chong, Mi Jang, Sung Hwan Lee, Ho Kyoung Hwang, Woo Jung Lee and Chang Moo Kang
Funding Agency and Grant Number	Funding Agency Grant Number Faculty Research Grant from Yonsei University College of Medicine 6-2017-0155
Corresponding Author	Chang Moo Kang, MD, PhD, Professor, Department of Surgery, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul 03722, South Korea. cmkang@yuhs.ac
Key Words	Pancreatic ductal adenocarcinoma; Secreted protein acidic and rich in cysteine; Tumor microenvironment; Stroma; Survival
Core Tip	This retrospective study investigated the prognostic significance of stromal secreted protein acidic and rich in cysteine (SPARC) expression in resected pancreatic ductal adenocarcinoma. High stromal SPARC expression is associated with inferior recurrence-free and overall survival, particularly in patients without adjuvant chemotherapy. External validation using The Cancer Genome Atlas-Pancreatic Adenocarcinoma cohort further supported the association between unfavorable prognosis and high SPARC expression. These findings suggest that stromal SPARC may serve as a meaningful prognostic biomarker and potential therapeutic target for pancreatic ductal adenocarcinoma.
Citation	Yang HY, Chong JU, Jang M, Lee SH, Hwang HK, Lee WJ, Kang CM. Stromal secreted protein acidic and rich in cysteine expression: A potential target for improved prognosis in patients with pancreatic cancer. World J Gastrointest Oncol 2025; In press

Received	2025-06-16 13:08
Peer-Review Started	2025-06-16 13:08
To Make the First Decision
Return for Revision	2025-07-10 09:13
Revised	2025-07-24 01:34
Second Decision	2025-09-30 02:46
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-09-30 08:53
Articles in Press	2025-09-30 08:53
Publication Fee Transferred	2025-07-29 09:48
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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