Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	110801
Country	China

Category	Oncology
Manuscript Type	Retrospective Study
Article Title	Clinical significance of systemic inflammation response index and platelet–lymphocyte ratio in patients with stage I-III gastric cancer
Manuscript Source	Unsolicited Manuscript
All Author List	En-Ze Zhou, Li-Xiang Zhang, Wen-Xiu Han, A-Man Xu and Zhi-Jian Wei
Funding Agency and Grant Number	Funding Agency Grant Number Key Projects of Anhui Provincial Department of Education No. 2023AH053330
Corresponding Author	Zhi-Jian Wei, Chief Physician, Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, No. 218 Jixi Road, Hefei 230032, Anhui Province, China. zhou11012025@163.com
Key Words	Nomogram; Prognosis; Systemic inflammation response index-platelet-to-lymphocyte ratio; Radical gastrectomy; Gastric cancer
Core Tip	In this study, 1071 patients with stage I-III gastric cancer who underwent radical gastrectomy at The First Affiliated Hospital of Anhui Medical University were followed up, and relevant clinicopathological factors were collected. A new scoring system called systemic inflammation response index (SIRI)-platelet-to-lymphocyte ratio (PLR) was calculated. Through univariate and multivariate Cox regression analyses, six indicators significantly associated with survival were identified: Age, tumor size, T stage, N stage, SIRI-PLR, and carcinoembryonic antigen. A nomogram model was then constructed and validated.
Citation	Zhou EZ, Zhang LX, Han WX, Xu AM, Wei ZJ. Clinical significance of systemic inflammation response index and platelet–lymphocyte ratio in patients with stage I-III gastric cancer. World J Gastrointest Surg 2025; In press

Received	2025-06-16 07:57
Peer-Review Started	2025-06-16 07:58
To Make the First Decision
Return for Revision	2025-06-19 06:44
Revised	2025-07-03 07:12
Second Decision	2025-08-12 02:56
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-08-13 10:14
Articles in Press	2025-08-13 10:14
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9366 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com