Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	110840
Country	Taiwan

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Cohort Study
Article Title	Secular trend in universal hepatocellular carcinoma prevention: Taiwan, Poland, and Belgium experience
Manuscript Source	Unsolicited Manuscript
All Author List	Zong-Ze Huang, Karol Żmudka, Valerio Ruggiano, Wan-Lun Hsu, Jessica Liu, Chun-Ju Chiang, Yong-Chen Chen and Vinchi Wang
Funding Agency and Grant Number
Corresponding Author	Yong-Chen Chen, Assistant Professor, PhD, Post-Baccalaureate Program in Nursing, College of Medicine, Fu Jen Catholic University, No. 510 Zhongzheng Road, Xinzhuang District, New Taipei City 242062, Taiwan. 137159@mail.fju.edu.tw
Key Words	Hepatocellular carcinoma; Hepatitis B virus; Hepatitis C virus; Metabolic syndrome; Cancer incidence
Core Tip	Due to differences in etiological factors and nationwide policies, limited evidence exists regarding the prevention outcomes of hepatocellular carcinoma in different countries. This retrospective cohort study presented the incidence, period, and cohort effects in hepatocellular carcinoma incidence between 2000 and 2019 in Taiwan, Poland, and Flanders, Belgium. Decreasing cohort effect in Taiwan and Poland resulted from effective hepatitis B virus immunization and viral hepatitis therapy. The increasing cohort effect in Flanders, Belgium, suggests that further measures to prevent the increasing risk of the hepatitis C virus are needed.
Citation	Huang ZZ, Żmudka K, Ruggiano V, Hsu WL, Liu J, Chiang CJ, Chen YC, Wang VC. Secular trend in universal hepatocellular carcinoma prevention: Taiwan, Poland, and Belgium experience. World J Gastrointest Oncol 2025; In press

Received	2025-06-18 10:49
Peer-Review Started	2025-06-18 10:50
To Make the First Decision
Return for Revision	2025-07-10 05:44
Revised	2025-07-23 17:23
Second Decision	2025-09-24 02:41
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-09-24 07:57
Articles in Press	2025-09-24 07:57
Publication Fee Transferred	2025-08-06 04:07
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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