Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	110864
Country	Greece

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Protective effects of treprostinil and ischemic preconditioning on hepatic ischemia-reperfusion injury and biomarkers in experimental study in rats
Manuscript Source	Invited Manuscript
All Author List	Christina Mouratidou, Efstathios T Pavlidis, Georgios Katsanos, Serafeim-Chrysovalantis Kotoulas, Maria Papaioannou, Georgios Tsoulfas, Emmanouela Apostolopoulou, Georgia D Brellou, Ioannis N Galanis and Theodoros E Pavlidis
Funding Agency and Grant Number
Corresponding Author	Theodoros E Pavlidis, MD, PhD, Professor, The Second Department of Propaedeutic Surgery, Hippokration General Hospital, School of Medicine, Aristotle University of Thessaloniki, Konstantinoupoleos 49, Thessaloniki 54642, Greece. pavlidth@auth.gr
Key Words	Hepatic ischemia-reperfusion injury; Liver surgery and transplantation; Oxidative stress; Prostaglandins; Prostacyclin; Treprostinil; Ischemic preconditioning
Core Tip	Hepatic ischemia-reperfusion injury is a serious condition that causes oxidative stress with a systemic inflammatory response. In addition to the liver, it may cause damage to remote organs, particularly the myocardium, with disastrous results. Consequently, its prevention is crucial, especially in liver surgery and transplantation. This experimental preclinical study in rats evaluated the cytoprotective effect of treprostinil, compared with that of ischemic preconditioning, on the liver and heart and assessed clearly useful biomarkers for better understanding the pathophysiology of systemic manifestations, thus opening new future perspectives for the further design of clinical trials assessing treprostinil efficacy.
Citation	Mouratidou C, Pavlidis ET, Katsanos G, Kotoulas SC, Papaioannou M, Tsoulfas G, Apostolopoulou E, Brellou GD, Galanis IN, Pavlidis TE. Protective effects of treprostinil and ischemic preconditioning on hepatic ischemia-reperfusion injury and biomarkers in experimental study in rats. World J Gastrointest Surg 2025; In press

Received	2025-06-18 11:14
Peer-Review Started	2025-06-18 11:15
To Make the First Decision
Return for Revision	2025-07-17 12:18
Revised	2025-07-24 05:57
Second Decision	2025-09-22 02:40
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-09-22 08:52
Articles in Press	2025-09-22 08:52
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ISSN	1948-9366 (online)
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