Publication Name	World Journal of Experimental Medicine
Manuscript ID	110893
Country	Greece

Category	Endocrinology & Metabolism
Manuscript Type	Minireviews
Article Title	Chronotherapeutic optimization of radioactive iodine therapy in differentiated thyroid cancer: The rationale for evening administration
Manuscript Source	Invited Manuscript
All Author List	Georgios Meristoudis, Christos Savvidis and Ioannis Ilias
Funding Agency and Grant Number
Corresponding Author	Ioannis Ilias, Director, MD, PhD, Department of Endocrinology, Hippocration General Hospital, No. 63 Evrou Street, Athens GR-11527, Greece. iiliasmd@yahoo.com
Key Words	Thyroid cancer; Radioactive iodine; Thyroid-stimulating hormone; Sodium-iodide symporter; Circadian rhythm; Chronotherapy; Treatment
Core Tip	Radioactive iodine (RAI) therapy is central to differentiated thyroid cancer management, relying on thyroid-stimulating hormone (TSH)-driven sodium-iodide symporter activity. Current protocols elevate TSH but overlook its circadian peak overnight. Aligning RAI administration with this peak via evening dosing may enhance iodine uptake, improve efficacy, reduce exposure, and optimize workflow. Preclinical evidence supports this chronotherapeutic approach, although clinical data are lacking. This review synthesizes existing evidence and proposes timed RAI administration as a novel strategy warranting prospective evaluation.
Citation	Meristoudis G, Savvidis C, Ilias I. Chronotherapeutic optimization of radioactive iodine therapy in differentiated thyroid cancer: The rationale for evening administration. World J Exp Med 2025; In press

Received	2025-06-18 06:49
Peer-Review Started	2025-06-18 06:49
To Make the First Decision
Return for Revision	2025-06-24 11:04
Revised	2025-06-26 11:45
Second Decision	2025-09-19 02:44
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-09-19 08:07
Articles in Press	2025-09-19 08:07
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-315x (online)
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