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Publication Name World Journal of Psychiatry
Manuscript ID 110916
Country China
Category Psychiatry
Manuscript Type Retrospective Study
Article Title Relationship between anxiety and depression, dyspnea severity, and pulmonary function in connective tissue disease-associated interstitial lung disease
Manuscript Source Unsolicited Manuscript
All Author List Zhu-Jing Zhu, Kai-Lin Liu and Huan-Ru Qu
Funding Agency and Grant Number
Funding Agency Grant Number
Construction of a High-level Research-oriented Traditional Chinese Medicine Hospital YC-2023-0901
Corresponding Author Huan-Ru Qu, MD, Department of Rheumatology and Immunology, Longhua Hospital Shanghai University of Traditional Chinese Medicine, No. 725 Wanping South Road, Xuhui District, Shanghai 200032, China. huan19215336566@163.com
Key Words Connective tissue disease-interstitial lung disease; Anxiety; Depression; Dyspnea; Pulmonary function; Prognosis
Core Tip This retrospective study investigates the association between anxiety, depression, dyspnea severity, and pulmonary function in patients with Connective tissue disease-associated interstitial lung disease (CTD-ILD). Results revealed that higher anxiety (generalized anxiety disorder-7) and depression (patient health questionnaire-9) scores were significantly correlated with worse pulmonary function (forced vital capacity, diffusing capacity of the lungs for carbon monoxide), more severe dyspnea (modified medical research council score), and elevated systemic inflammation (C-reactive protein, erythrocyte sedimentation rate). Moreover, psychological distress emerged as an independent predictor of pulmonary function decline. These findings underscore the importance of routine psychological assessment and timely intervention in CTD-ILD management to prevent deterioration and improve prognosis.
Citation Zhu ZJ, Liu KL, Qu HR. Relationship between anxiety and depression, dyspnea severity, and pulmonary function in connective tissue disease-associated interstitial lung disease. World J Psychiatry 2025; In press
Received
2025-07-29 08:48
Peer-Review Started
2025-07-29 08:48
To Make the First Decision
Return for Revision
2025-08-19 06:40
Revised
2025-08-27 15:17
Second Decision
2025-10-10 02:33
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief
2025-10-10 07:09
Articles in Press
2025-10-10 07:09
Publication Fee Transferred
2025-08-29 12:40
Edit the Manuscript by Language Editor
Typeset the Manuscript
ISSN 2220-3206 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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