Publication Name	World Journal of Experimental Medicine
Manuscript ID	110936
Country	Türkiye

Category	Dermatology
Manuscript Type	Systematic Reviews
Article Title	Efficacy of beta-blockers in the treatment of hematidrosis: A systematic review
Manuscript Source	Invited Manuscript
All Author List	Ahmet Alperen Palabiyik
Funding Agency and Grant Number
Corresponding Author	Ahmet Alperen Palabiyik, Lecturer, PhD, Department of Nursing, Department of Nursing, Faculty of Health Sciences, Ardahan University, Çamlıçatak, Ardahan 75002, Turkey, <italic>Correspondence to</italic>: Dr Ahmet Alperen Palabiyik, Department of Nursing, Faculty of Health Sciences, Ardahan University, Yenisey Campus, Çamlıçatak, Ardahan 75002, Turkey, E-mail: <email>ahmetalperenpalabiyik@ardahan.edu.tr</email>, Ardahan 75000, Türkiye. ahmetalperenpalabiyik@ardahan.edu.tr
Key Words	Hematidrosis; Beta-blockers; Propranolol; Adrenergic inhibition; Psychogenic bleeding; Stress-related disorders; Sympathetic overactivation
Core Tip	Hematidrosis is an extremely rare condition characterized by spontaneous bleeding through intact skin, often triggered by emotional stress. This systematic review evaluates the efficacy and safety of beta-blockers, particularly propranolol, in managing hematidrosis. The findings indicate that propranolol can significantly reduce symptom frequency and severity, especially when combined with psychotherapy. By focusing solely on clinical studies involving beta-blocker use, this review bridges a critical gap in the literature and highlights the need for standardized treatment protocols and controlled clinical trials. The results support a multidisciplinary approach targeting both physiological and psychological triggers.
Citation	Palabiyik AA. Efficacy of beta-blockers in the treatment of hematidrosis: A systematic review. World J Exp Med 2025; In press

Received	2025-06-19 05:56
Peer-Review Started	2025-06-19 05:57
To Make the First Decision
Return for Revision	2025-07-18 07:29
Revised	2025-07-27 21:23
Second Decision	2025-10-24 02:43
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-10-24 11:55
Articles in Press	2025-10-24 11:55
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ISSN	2220-315x (online)
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