Publication Name	World Journal of Psychiatry
Manuscript ID	110968
Country	China

Category	Psychiatry
Manuscript Type	Clinical Trials Study
Article Title	Safety and efficacy of different initial doses of lurasidone in the schizophrenia treatment: A multi-center, randomized, open-label study
Manuscript Source	Unsolicited Manuscript
All Author List	Qi Liu, Min-Cai Qian, Zhi-Fen Liu, Fang Dong, Deng-Tang Liu, Ming-Li Li, Yu-Ping Ning, Xiao-Ping Wang, Tie-Bang Liu, Qi Wu, Tao Li and Xin Yu
Funding Agency and Grant Number
Corresponding Author	Xin Yu, PhD, Department of Psychiatry, Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), No. 51 Huayuanbei Road, Beijing 100191, China. yuxin@bjmu.edu.cn
Key Words	Schizophrenia; Discontinuation rate; Efficacy; Safety; Lurasidone
Core Tip	This randomized, multicenter study innovatively compares initial lurasidone doses (40 mg/day vs 80 mg/day) in Chinese patients with acute schizophrenia, addressing a critical gap in dose optimization. Key findings reveal no significant difference in discontinuation rates due to adverse events (3.03% vs 5.10%, P = 0.707), affirming the tolerability of higher initial dosing. Notably, the 80 mg/day group showed superior early improvement in Positive and Negative Syndrome Scale positive subscale scores (P < 0.05) without exacerbating metabolic risks. These results challenge conventional dosing paradigms, suggesting 80 mg/day as a viable initial option for rapid symptom control, while maintaining safety.
Citation	Liu Q, Qian MC, Liu ZF, Dong F, Liu DT, Li ML, Ning YP, Wang XP, Liu TB, Wu Q, Li T, Yu X. Safety and efficacy of different initial doses of lurasidone in the schizophrenia treatment: A multi-center, randomized, open-label study. World J Psychiatry 2025; In press

Received	2025-06-20 04:02
Peer-Review Started	2025-06-20 04:02
To Make the First Decision
Return for Revision	2025-07-01 02:47
Revised	2025-07-10 09:32
Second Decision	2025-08-15 02:56
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-08-15 11:15
Articles in Press	2025-08-15 11:15
Publication Fee Transferred	2025-07-16 03:31
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3206 (online)
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