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Articles in Press
7/31/2025 7:18:26 AM | Browse: 34 | Download: 0
Category |
Gastroenterology & Hepatology |
Manuscript Type |
Observational Study |
Article Title |
Serum gastrin and Helicobacter pylori infection correlate with tumor aggressiveness and prognosis in gastric cancer
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Manuscript Source |
Unsolicited Manuscript |
All Author List |
Jun-Wen Huang, Chen Lin, Chen-Jia Lu, Hua-Shou Wang and Dan-Dan Zou |
Funding Agency and Grant Number |
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Corresponding Author |
Chen Lin, Department of Pathology, People’s Hospital of Longhua District, No. 38 Jinglong Jianshe Road, Longhua District, Shenzhen 518110, Guangdong Province, China. chenlincc2024@163.com |
Key Words |
Gastrin; Gastric cancer; Helicobacter pylori; Pathological characteristics; Survival curve |
Core Tip |
This study explores the clinical relevance of serum gastrin and Helicobacter pylori infection in gastric cancer. Among 226 patients, elevated serum gastrin, but not Helicobacter pylori status, was significantly associated with advanced tumor stage, lymphatic metastasis, and poor differentiation. Notably, gastrin-positive patients had worse overall survival. These findings suggest that hypergastrinemia may serve as a biomarker of tumor aggressiveness and prognosis in gastric cancer, offering potential targets for risk stratification and therapeutic intervention. |
Citation |
Huang JW, Lin C, Lu CJ, Wang HS, Zou DD. Serum gastrin and Helicobacter pylori infection correlate with tumor aggressiveness and prognosis in gastric cancer. World J Gastrointest Oncol 2025; In press |
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Received |
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2025-06-20 05:42 |
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Peer-Review Started |
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2025-06-20 05:42 |
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To Make the First Decision |
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Return for Revision |
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2025-06-30 06:32 |
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Revised |
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2025-07-02 02:13 |
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Second Decision |
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2025-07-31 02:40 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-07-31 07:18 |
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Articles in Press |
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2025-07-31 07:18 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2025-08-04 22:47 |
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Typeset the Manuscript |
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ISSN |
1948-5204 (online) |
Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
Website |
http://www.wjgnet.com |
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