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Publication Name World Journal of Gastrointestinal Oncology
Manuscript ID 110981
Country China
Category Gastroenterology & Hepatology
Manuscript Type Observational Study
Article Title Serum gastrin and Helicobacter pylori infection correlate with tumor aggressiveness and prognosis in gastric cancer
Manuscript Source Unsolicited Manuscript
All Author List Jun-Wen Huang, Chen Lin, Chen-Jia Lu, Hua-Shou Wang and Dan-Dan Zou
Funding Agency and Grant Number
Corresponding Author Chen Lin, Department of Pathology, People’s Hospital of Longhua District, No. 38 Jinglong Jianshe Road, Longhua District, Shenzhen 518110, Guangdong Province, China. chenlincc2024@163.com
Key Words Gastrin; Gastric cancer; Helicobacter pylori; Pathological characteristics; Survival curve
Core Tip This study explores the clinical relevance of serum gastrin and Helicobacter pylori infection in gastric cancer. Among 226 patients, elevated serum gastrin, but not Helicobacter pylori status, was significantly associated with advanced tumor stage, lymphatic metastasis, and poor differentiation. Notably, gastrin-positive patients had worse overall survival. These findings suggest that hypergastrinemia may serve as a biomarker of tumor aggressiveness and prognosis in gastric cancer, offering potential targets for risk stratification and therapeutic intervention.
Citation Huang JW, Lin C, Lu CJ, Wang HS, Zou DD. Serum gastrin and Helicobacter pylori infection correlate with tumor aggressiveness and prognosis in gastric cancer. World J Gastrointest Oncol 2025; In press
Received
2025-06-20 05:42
Peer-Review Started
2025-06-20 05:42
To Make the First Decision
Return for Revision
2025-06-30 06:32
Revised
2025-07-02 02:13
Second Decision
2025-07-31 02:40
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief
2025-07-31 07:18
Articles in Press
2025-07-31 07:18
Publication Fee Transferred
Edit the Manuscript by Language Editor
2025-08-04 22:47
Typeset the Manuscript
ISSN 1948-5204 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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