Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	110981
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Observational Study
Article Title	Serum gastrin and Helicobacter pylori infection correlate with tumor aggressiveness and prognosis in gastric cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Jun-Wen Huang, Chen Lin, Chen-Jia Lu, Hua-Shou Wang and Dan-Dan Zou
Funding Agency and Grant Number
Corresponding Author	Chen Lin, Department of Pathology, People’s Hospital of Longhua District, No. 38 Jinglong Jianshe Road, Longhua District, Shenzhen 518110, Guangdong Province, China. chenlincc2024@163.com
Key Words	Gastrin; Gastric cancer; Helicobacter pylori; Pathological characteristics; Survival curve
Core Tip	This study explores the clinical relevance of serum gastrin and Helicobacter pylori infection in gastric cancer. Among 226 patients, elevated serum gastrin, but not Helicobacter pylori status, was significantly associated with advanced tumor stage, lymphatic metastasis, and poor differentiation. Notably, gastrin-positive patients had worse overall survival. These findings suggest that hypergastrinemia may serve as a biomarker of tumor aggressiveness and prognosis in gastric cancer, offering potential targets for risk stratification and therapeutic intervention.
Citation	Huang JW, Lin C, Lu CJ, Wang HS, Zou DD. Serum gastrin and Helicobacter pylori infection correlate with tumor aggressiveness and prognosis in gastric cancer. World J Gastrointest Oncol 2025; In press

Received	2025-06-20 05:42
Peer-Review Started	2025-06-20 05:42
To Make the First Decision
Return for Revision	2025-06-30 06:32
Revised	2025-07-02 02:13
Second Decision	2025-07-31 02:40
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-07-31 07:18
Articles in Press	2025-07-31 07:18
Publication Fee Transferred
Edit the Manuscript by Language Editor	2025-08-04 22:47
Typeset the Manuscript

ISSN	1948-5204 (online)
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