Publication Name	World Journal of Clinical Pediatrics
Manuscript ID	111021
Country	Italy

Category	Pediatrics
Manuscript Type	Minireviews
Article Title	Therapeutic interventions and pulmonary function in pediatric patients with post-infectious bronchiolitis obliterans
Manuscript Source	Invited Manuscript
All Author List	Serena Chiellino
Funding Agency and Grant Number
Corresponding Author	Serena Chiellino, MD, Paediatric and Neonatologic Unit, Santo Stefano Hospital, Via Suor Niccolina Infermiera 20/22, Prato 59100, Tuscany, Italy. serenachiellino90@gmail.com
Key Words	Post-infectious bronchiolitis obliterans; Pediatric pulmonary function; Children; Therapeutic interventions; Spirometric monitoring
Core Tip	Post-infectious bronchiolitis obliterans leads to permanent small-airway obstruction and significant spirometric deficits in children, notably reduced forced expiratory volume in one second and forced expiratory flow at 25%-75% with poor bronchodilator response, while diffusing capacity of the lung for carbon monoxide often remains normal. This narrative review links these pulmonary function parameters with therapeutic interventions, showing that early use of inhaled or systemic corticosteroids and macrolides can stabilize or modestly improve lung function. Emerging combination regimens, such as fluticasone-azithromycin-montelukast, show promise but need further validation. Integrating regular spirometric monitoring with tailored anti-inflammatory strategies may optimize clinical outcomes and underlines the need for prospective studies.
Citation	Chiellino S. Therapeutic interventions and pulmonary function in pediatric patients with post-infectious bronchiolitis obliterans. World J Clin Pediatr 2025; In press

Received	2025-06-23 10:33
Peer-Review Started	2025-06-23 10:35
To Make the First Decision
Return for Revision	2025-07-02 08:50
Revised	2025-07-10 15:52
Second Decision	2025-11-06 02:42
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-11-07 03:48
Articles in Press	2025-11-07 03:48
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2219-2808 (online)
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