Publication Name	World Journal of Critical Care Medicine
Manuscript ID	111054
Country	India

Category	Critical Care Medicine
Manuscript Type	Minireviews
Article Title	Ivabradine in acute care: Revisiting the funny current in critical care context
Manuscript Source	Invited Manuscript
All Author List	Arun Mukesh, Ankur Sharma and Nikhil Kothari
Funding Agency and Grant Number
Corresponding Author	Ankur Sharma, Additional Professor, Consultant, MD, Department of Trauma and Emergency (Anaesthesiology and Critical Care), All India Institute of Medical Sciences, Corresponding Author: Ankur Sharma, E-mail: <email>ankuranaesthesia@gmail.com</email>, Jodhpur 342008, Rājasthān, India. ankuranaesthesia@gmail.com
Key Words	Ivabradine; Heart rate control; Tachycardia; Heart failure; Beta blocker; Acute care
Core Tip	Ivabradine reduces heart rate by specifically inhibiting the funny current in the sinoatrial node, without impacting myocardial contractility or blood pressure. This distinctive characteristic renders it an appealing choice for critically sick patients for whom beta-blockers are contraindicated or poorly tolerated. Recent studies corroborate its significance in acute scenarios, including acute decompensated heart failure, acute coronary syndrome, and sepsis-induced tachycardia, where a higher heart rate exacerbates outcomes. This review looks at the mechanism of action, clinical uses, comparative effectiveness, and safety profile.
Citation	Mukesh A, Sharma A, Kothari N. Ivabradine in acute care: Revisiting the funny current in critical care context. World J Crit Care Med 2025; In press

Received	2025-06-23 13:41
Peer-Review Started	2025-06-23 13:41
To Make the First Decision
Return for Revision	2025-06-27 05:42
Revised	2025-07-08 08:36
Second Decision	2025-10-09 02:35
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-10-10 06:54
Articles in Press	2025-10-10 06:54
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3141(online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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