Publication Name	World Journal of Orthopedics
Manuscript ID	111068
Country	United States

Category	Orthopedics
Manuscript Type	Meta-Analysis
Article Title	Outcomes of autologous bone grafts vs bone substitutes in tibial plateau fractures: A meta-analysis
Manuscript Source	Unsolicited Manuscript
All Author List	Ali Saad Alshahrani, Yazan Jumah Alalwani, Nihal Mushabb Alqahtani, Abdullah Shafi D Alanazi, Ahmed Khaled Almarri, Shatha Saud Alqurashi, Deemah Khalid Ghazi, Abdullah Musaaed Alsalamah, Rahaf Hamdan Alruwaili, Ahmed Y Azzam and Fawaz Alanii
Funding Agency and Grant Number
Corresponding Author	Ahmed Y Azzam, Director of Clinical Research and Clinical Artificial Intelligence, ASIDE Healthcare, 16192 Coastal Highway, Lewes, Delaware 19958, United States. ahmedyazzam@gmail.com
Key Words	Tibial plateau fractures; Tibia; Bone grafts; Bone substitutes; Synthetic bone material
Core Tip	This meta-analysis of seven randomized controlled trials involving 424 patients demonstrates that bone substitutes provide equivalent structural outcomes to autologous bone grafts in tibial plateau fractures while offering significant procedural advantages. The study introduces a novel combined outcome scoring system integrating structural, procedural, and complication domains, revealing bone substitutes reduce blood loss by 70-90 mL and operative time, particularly in Asian populations. Geographic variations showed Western studies had 45% higher secondary collapse risk with autografts. These findings support bone substitutes as viable alternatives across all fracture complexities, challenging the traditional gold standard approach and offering particular benefits in resource-limited settings.
Citation	Alshahrani AS, Alalwani YJ, Alqahtani NM, Alanazi ASD, Almarri AK, Alqurashi SS, Ghazi DK, Alsalamah AM, Alruwaili RH, Azzam AY, Alanii F. Outcomes of autologous bone grafts versus bone substitutes in tibial plateau fractures: A meta-analysis. World J Orthop 2025; In press

Received	2025-06-23 06:20
Peer-Review Started	2025-06-23 06:20
To Make the First Decision
Return for Revision	2025-07-19 01:53
Revised	2025-08-03 07:07
Second Decision	2025-08-27 02:39
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-08-27 08:47
Articles in Press	2025-08-27 08:47
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ISSN	2218-5836 (online)
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