Publication Name	World Journal of Critical Care Medicine
Manuscript ID	111114
Country	India

Category	Critical Care Medicine
Manuscript Type	Systematic Reviews
Article Title	Burden and impact of acute kidney injury in acute liver failure: A systematic review
Manuscript Source	Invited Manuscript
All Author List	Armin Ahmed, Medhavi Gautam, Afzal Azim, Banadana Chakravarti and Meenakshi Tiwari
Funding Agency and Grant Number
Corresponding Author	Armin Ahmed, Critical Care Medicine, King George's Medical University, Chowk, Lucknow 226003, Uttar Pradesh, India. drarminahmed@gmail.com
Key Words	Acute liver failure; Acute kidney injury; Systematic review; Paracetamol related acute liver failure; Transient kidney injury; Persistent kidney injury
Core Tip	This systematic review of nine studies (6031 patients) found that acute kidney injury (AKI) occurs in 62.9% of acute liver failure (ALF) cases, with incidence varying from 37.9% to 79.1%. Drug-induced ALF, especially paracetamol-related, was the predominant etiology in most cohorts, while viral hepatitis was more common in Asia. Few studies identified independent AKI risk factors, with systemic inflammation, shock, and tumor necrosis factor-alpha elevation among them. AKI was consistently associated with increased mortality and lower transplant-free survival. Significant gaps include a lack of etiological data, pathophysiological insights, and representation from low- and middle-income countries, highlighting the need for standardized definitions and multicenter research.
Citation	Ahmed A, Gautam M, Azim A, Chakravarti B, Tiwari M. Burden and impact of acute kidney injury in acute liver failure: A systematic review. World J Crit Care Med 2025; In press

Received	2025-06-24 08:54
Peer-Review Started	2025-06-24 08:54
To Make the First Decision
Return for Revision	2025-07-21 08:39
Revised	2025-08-14 08:40
Second Decision	2025-11-14 02:42
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-11-14 08:25
Articles in Press	2025-11-14 08:25
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ISSN	2220-3141(online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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