Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	111138
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Impact of primary colorectal cancer site on surgical outcomes for liver metastases: A retrospective study
Manuscript Source	Unsolicited Manuscript
All Author List	Da-Mao Liu, Xian-Yu Yang, Hui-Hua Zheng, Pan-Min Chen, Shu-Kun Zeng and Yu-Feng Wei
Funding Agency and Grant Number
Corresponding Author	Yu-Feng Wei, MD, Department of General Surgery, The Affiliated Hospital of Jiangxi University of Chinese Medicine, No. 445 Bayi Avenue, Donghu District, Nanchang 330200, Jiangxi Province, China. wy18070036305@163.com
Key Words	Colorectal cancer; Tumor metastasis; Liver tumor recurrence; Resection of metastatic tumor; D-dimer; Risk assessment
Core Tip	This retrospective study investigates how the primary tumor location in colorectal cancer affects clinical outcomes following liver metastasis resection. Among 178 patients, right-sided colon cancers were associated with significantly higher recurrence rates, postoperative complications, and worse survival compared to left-sided and rectal cancers. Multivariate analysis identified right-sided origin, lymph node metastasis, elevated D-dimer, hypoalbuminemia, poor neoadjuvant response, and high clinical risk scores as independent predictors of recurrence. These findings highlight the prognostic importance of tumor site and support site-specific treatment strategies for patients with colorectal liver metastases to improve surgical safety and long-term outcomes.
Citation	Liu DM, Yang XY, Zheng HH, Chen PM, Zeng SK, Wei YF. Impact of primary colorectal cancer site on surgical outcomes for liver metastases: A retrospective study. World J Gastrointest Surg 2025; In press

Received	2025-07-15 09:30
Peer-Review Started	2025-07-15 09:30
To Make the First Decision
Return for Revision	2025-08-06 08:36
Revised	2025-08-19 14:34
Second Decision	2025-09-25 02:36
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-09-25 03:35
Articles in Press	2025-09-25 03:35
Publication Fee Transferred	2025-08-26 06:25
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9366 (online)
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