Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	111171
Country	China

Category	Oncology
Manuscript Type	Retrospective Study
Article Title	Tumour chemotherapy sensitivity test may predict clinical outcomes in colorectal cancer patients receiving oxaliplatin and fluoropyrimidine-based regimens
Manuscript Source	Unsolicited Manuscript
All Author List	Si-Jia Li, Yi-Xuan Lu, Fang-Yue Zheng, Yi-Cong Bian, Li-Yan Miao and Chen-Rong Huang
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China U24A20765, T2321005 Jiangsu Provincial Science and Technology Plan Special Fund BM2023003 Jiangsu Provincial Medical Key Discipline ZDXK202247 Priority Academic Program Development of the Jiangsu Higher Education Institutes Jiangsu Engineering Research Center on Drug Evaluation and Translation of Organoids/Organ Chip (2024) Science and Technology Plan of Suzhou SKYD2023183 Research Project Established by Chinese Pharmaceutical Association Hospital Pharmacy Department CPA-Z05-ZC-2023002 Gusu Health Talent Research Project GSWS2022015
Corresponding Author	Chen-Rong Huang, PhD, Department of Pharmacy, The First Affiliated Hospital of Soochow University, No. 899 Pinghai Road, Suzhou 215006, Jiangsu Province, China. huangchenrong@suda.edu.cn
Key Words	Colorectal cancer; Precision oncology; Adenosine triphosphate-based tumour chemotherapy sensitivity test; Clinical prediction model; Chemosensitivity; 5-fluorouracil; Oxaliplatin
Core Tip	In this study, retrospectively evaluated the clinical application of adenosine triphosphate-based tumour chemotherapy sensitivity test (ATP-TCA) and revealed that it is an independent prognostic factor for disease-free survival in patients with resectable colorectal cancer. Additionally, an ATP-TCA-sensitive chemotherapy regimen was shown to significantly improve overall survival and disease-free survival in colorectal patients in stage III. Although the necessity for further validation, this study provides evidence supporting the extension of ATP-TCA assays to combination chemotherapy regimens for colorectal cancer while providing a theoretical basis and perspective for future advancements in personalized medicine.
Citation	Li SJ, Lu YX, Zheng FY, Bian YC, Miao LY, Huang CR. Tumour chemotherapy sensitivity test may predict clinical outcomes in colorectal cancer patients receiving oxaliplatin and fluoropyrimidine-based regimens. World J Gastrointest Oncol 2025; In press

Received	2025-06-25 06:47
Peer-Review Started	2025-06-25 06:48
To Make the First Decision
Return for Revision	2025-08-15 04:05
Revised	2025-08-27 17:34
Second Decision	2025-09-28 02:42
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-09-28 10:45
Articles in Press	2025-09-28 10:45
Publication Fee Transferred	2025-08-28 13:42
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Typeset the Manuscript

ISSN	1948-5204 (online)
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