Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	111202
Country	Türkiye

Category	Oncology
Manuscript Type	Retrospective Cohort Study
Article Title	Clinicopathological features of patients undergoing surgery for pancreatic cancer with very early postoperative recurrence
Manuscript Source	Invited Manuscript
All Author List	Hüseyin Fahri Martlı, Hüseyin Oytun İnsan, Mert Altaş, Betül Erişmiş, Velihan Çayhan, Osman Ersoy, Mehmet Keşkek and Mesut Tez
Funding Agency and Grant Number
Corresponding Author	Mesut Tez, Department of Surgery, University of Health Sciences, Ankara City Hospital, No. 1 Bilkent Street, District of Universities, Ankara 06800, Türkiye. mesuttez@yahoo.com
Key Words	Pancreatic ductal adenocarcinoma; Very early recurrence; Poorly differentiated tumors; Tumor location; Red cell distribution width; Machine learning
Core Tip	This study investigates very early recurrence (VER), defined as recurrence within 12 weeks post-surgery, in pancreatic ductal adenocarcinoma (PDAC) patients. It identifies poorly differentiated tumors as a key predictor of VER, linked to higher six-month mortality, offering a novel prognostic marker. Unlike prior research, it highlights pancreatic head tumors’ association with VER, challenging body/tail dominance theories. The findings suggest tailored surveillance and molecular studies to improve outcomes, marking a significant step toward personalized PDAC management.
Citation	Martlı HF, İnsan HO, Altaş M, Erişmiş B, Çayhan V, Ersoy O, Keşkek M, Tez M. Clinicopathological features of patients undergoing surgery for pancreatic cancer with very early postoperative recurrence. World J Gastrointest Surg 2025; In press

Received	2025-06-25 06:15
Peer-Review Started	2025-06-25 06:23
To Make the First Decision
Return for Revision	2025-07-03 14:19
Revised	2025-07-03 19:27
Second Decision	2025-09-15 02:39
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-09-15 06:47
Articles in Press	2025-09-15 06:47
Publication Fee Transferred	2025-07-04 09:16
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9366 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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