Publication Name	World Journal of Clinical Oncology
Manuscript ID	111213
Country	China

Category	Medical Laboratory Technology
Manuscript Type	Basic Study
Article Title	Abnormal expression and potential clinical value of oncogenic Krüppel-like factor-5 in lung squamous cell carcinoma
Manuscript Source	Unsolicited Manuscript
All Author List	Yang Shi, Wen-Li Sai, Jin-Liang Chen, Li-Wei Qiu, Min Yao, Jun Zhao and Deng-Fu Yao
Funding Agency and Grant Number	Funding Agency Grant Number Jiangsu Commission of Health of China M2020096
Corresponding Author	Deng-Fu Yao, MD, PhD, Postdoc, Professor, Research Center of Clinical Medicine, Affiliated Hospital of Nantong University, No. 20 West Temple Road, Nantong 226001, Jiangsu Province, China. yaodf@ahnmc.com
Key Words	Targeted therapy; Xenograft growth; Biological behaviors; Diagnostic biomarker; Lung adenocarcinoma; Lung squamous-cell carcinoma; Lung cancer; Oncogenic Krüppel-like factor-5
Core Tip	Krüppel-like factor-5 (KLF5) is upregulated in lung cancer, with stronger expression in lung squamous-cell carcinoma (LUSC) than in lung adenocarcinoma. Upregulated KLF5 expression was associated with the proliferation, migration and cell cycle of lung cancer cells, which is likely a favorable diagnostic biomarker of LUSC and could be a new molecular target for lung cancer. Furthermore, KLF5 might exert its oncogenic regulatory effects on the growth of lung cancer by increasing metastasis or progression by activating related signaling pathways.
Citation	Shi Y, Sai WL, Chen JL, Qiu LW, Yao M, Zhao J, Yao DF. Abnormal expression and potential clinical value of oncogenic Krüppel-like factor-5 in lung squamous cell carcinoma. World J Clin Oncol 2025; In press

Received	2025-06-26 11:14
Peer-Review Started	2025-06-26 11:14
To Make the First Decision
Return for Revision	2025-07-31 07:59
Revised	2025-08-04 02:13
Second Decision	2025-09-25 02:39
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-09-25 07:33
Articles in Press	2025-09-25 07:33
Publication Fee Transferred	2025-08-05 01:54
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2218-4333 (online)
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