Publication Name	World Journal of Diabetes
Manuscript ID	111230
Country	United Kingdom

Category	Endocrinology & Metabolism
Manuscript Type	Meta-Analysis
Article Title	Role of automated insulin delivery in managing insulin-treated outpatients with type 2 diabetes: A systematic review and meta-analysis
Manuscript Source	Invited Manuscript
All Author List	Abul Bashar Mohammad Kamrul-Hasan, Joseph M Pappachan, Lakshmi Nagendra, Nazma Akter, Sweekruti Jena, Deep Dutta and Sunil Nair
Funding Agency and Grant Number
Corresponding Author	Joseph M Pappachan, FRCP, MD, MRCP, Professor, Senior Researcher, Faculty of Science, Manchester Metropolitan University, Lower Ormond Street, Manchester M15 6BH, Greater Manchester, United Kingdom. drpappachan@yahoo.co.in
Key Words	Automated insulin delivery; Type 2 diabetes; Time in range; Glycated hemoglobin; Meta-analysis
Core Tip	This is the first systematic review and meta-analysis specifically targeting the efficacy and safety of automated insulin delivery (AID) systems in patients with type 2 diabetes in the outpatient setting. Analyzing six randomized controlled trials and nine single-arm studies involving 28985 participants, we observed that AID systems enhance glycemic control, evidenced by larger decreases in glycated hemoglobin and improved continuous glucose monitoring metrics compared to standard treatment. AID use increases time in range, reduces time above target glucose, and maintains similar rates of hypoglycemia and serious adverse events. While AID slightly increases the risk of device deficiency, safety is still within acceptable limits. The results indicate short-term effectiveness, but larger and longer-term studies are necessary to confirm the benefits and assess cost-effectiveness.
Citation	Kamrul-Hasan ABM, Pappachan JM, Nagendra L, Akter N, Jena S, Dutta D, Nair S. Role of automated insulin delivery in managing insulin-treated outpatients with type 2 diabetes: A systematic review and meta-analysis. World J Diabetes 2025; In press

Received	2025-06-26 07:12
Peer-Review Started	2025-06-30 08:37
To Make the First Decision
Return for Revision	2025-08-08 07:57
Revised	2025-08-14 16:35
Second Decision	2025-09-15 02:39
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-09-15 10:26
Articles in Press	2025-09-15 10:26
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9358 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com