Publication Name	World Journal of Gastroenterology
Manuscript ID	111261
Country	Croatia

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Cohort Study
Article Title	Clinical impact of multidrug-resistant organisms in liver cirrhosis: A retrospective cohort study in the intensive care setting
Manuscript Source	Invited Manuscript
All Author List	Iva Kosuta, Jaksa Babel, Viktor Domislovic, Frano Susak, Laura Peretin, Dijana Varda Brkic, Ivana Mareković, Radovan Radonic and Anna Mrzljak
Funding Agency and Grant Number
Corresponding Author	Iva Kosuta, Consultant, MD, PhD, Division of Intensive Care, Department of Internal Medicine, University Hospital Centre Zagreb, Ulica Mije Kišpatića 12, Zagreb 10000, Croatia. ivakosuta@gmail.com
Key Words	Liver cirrhosis; Acute-on-chronic liver failure; Critical care; Multidrug-resistant organisms; Colonization; Infection
Core Tip	This retrospective intensive care unit cohort study evaluated the impact of multidrug-resistant colonization in patients with liver cirrhosis. While colonization was common, especially in those with acute-on-chronic liver failure, it was not independently linked to infection or short-term mortality. However, high concordance between colonizing and infecting strains supports its role in guiding empirical antibiotic therapy once infection is suspected. These findings highlight the importance of early screening, local resistance data, and tailored empirical treatment to improve outcomes of critically ill patients with cirrhosis.
Citation	Kosuta I, Babel J, Domislovic V, Susak F, Peretin L, Varda Brkic D, Marekovic I, Radonic R, Mrzljak A. Clinical impact of multidrug-resistant organisms in liver cirrhosis: A retrospective cohort study in the intensive care setting. World J Gastroenterol 2025; In press

Received	2025-06-26 12:40
Peer-Review Started	2025-06-26 12:40
To Make the First Decision
Return for Revision	2025-07-14 09:44
Revised	2025-07-25 18:24
Second Decision	2025-09-15 02:39
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-09-15 05:06
Articles in Press	2025-09-15 05:06
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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