Publication Name	World Journal of Gastrointestinal Pathophysiology
Manuscript ID	111306
Country	United States

Category	Gastroenterology & Hepatology
Manuscript Type	Letter to the Editor
Article Title	Drug-induced liver injury from high-dose intravenous methylprednisolone: A rare but known adverse effect
Manuscript Source	Invited Manuscript
All Author List	Kevan English
Funding Agency and Grant Number
Corresponding Author	Kevan English, MD, Department of Internal Medicine, University of Nebraska Medical Center, 42nd and Emile, Omaha, NE 68198, United States. keenglish@unmc.edu
Key Words	Methylprednisolone; Drug-induced liver injury; Corticosteroids; Hepatotoxicity; Transaminitis; Glucocorticoids; Multiple sclerosis; Inflammation
Core Tip	Corticosteroids are widely used in the treatment of various diseases. In general, these medications are considered safe. However, several recent cases have reported severe liver injury with high-dose methylprednisolone (Methyl-PNL). This article reports a case of asymptomatic hepatitis from high-dose Methyl-PNL that resolved with medication discontinuation. This known adverse effect should not preclude providers from treating various clinical conditions with high-dose Methyl-PNL. However, it should not be surprising if acute hepatitis or severe liver injury occurs as an adverse reaction, especially with high doses. We call for more providers to be aware of this idiosyncratic and rare drug side effect.
Citation	English K. Drug-induced liver injury from high-dose intravenous methylprednisolone: A rare but known adverse effect. World J Gastrointest Pathophysiol 2025; In press

Received	2025-06-27 01:06
Peer-Review Started	2025-06-27 01:06
To Make the First Decision
Return for Revision	2025-07-16 08:38
Revised	2025-07-30 01:54
Second Decision	2025-09-15 02:42
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-09-17 10:28
Articles in Press	2025-09-17 10:28
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2150-5330 (online)
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