Publication Name	World Journal of Stem Cells
Manuscript ID	111341
Country	China

Category	Cell Biology
Manuscript Type	Letter to the Editor
Article Title	Human umbilical cord mesenchymal stromal cell-derived extracellular vesicles alleviate radiation induced pulmonary fibrosis
Manuscript Source	Unsolicited Manuscript
All Author List	Jing-Jing Wang and Hong-Jie Xu
Funding Agency and Grant Number
Corresponding Author	Hong-Jie Xu, Associate Professor, The Fifth Affiliated Hospital, Guangzhou Medical University, No. 188 Kaiyuan Avenue, Huangpu District, Guangzhou 510535, Guangdong Province, China. xuhongjie316@163.com
Key Words	Human umbilical cord mesenchymal stromal cells; Exosomes; Extracellular vesicles; Pulmonary fibrosis; Inflammation
Core Tip	This commentary examines the study by Wang et al on the role of human umbilical cord mesenchymal stromal cell-derived exosomes in alleviating radiation induced pulmonary fibrosis. However, some issues are worth discussing. First, regarding the definitions of MSC and exosomes, according to the latest standards, mesenchymal stromal cell should represent mesenchymal stromal cell, and the so-called exosomes should be extracellular vesicles. Secondly, there are some imprecise or incorrect parts in the text that need to be clarified, especially the evidence for the AKT signaling pathway may be insufficient. Thirdly, this article more systematically discusses the current progress of extracellular vesicles in the treatment of pulmonary fibrosis.
Citation	Wang JJ, Xu HJ. Human umbilical cord mesenchymal stromal cell-derived extracellular vesicles alleviate radiation induced pulmonary fibrosis. World J Stem Cells 2025; In press

Received	2025-07-04 00:38
Peer-Review Started	2025-07-04 00:39
To Make the First Decision
Return for Revision	2025-07-15 08:02
Revised	2025-07-21 03:37
Second Decision	2025-09-03 02:46
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-09-03 08:49
Articles in Press	2025-09-03 08:49
Publication Fee Transferred
Edit the Manuscript by Language Editor	2025-09-05 18:27
Typeset the Manuscript

ISSN	1948-0210 (online)
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