Publication Name	World Journal of Gastroenterology
Manuscript ID	111478
Country	South Korea

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Twenty-year temporal trends, risk profiles, and prognostic value of clinicopathological features in gallbladder cancer following cholecystectomy
Manuscript Source	Unsolicited Manuscript
All Author List	Jeongyeon An, So-Hyun Ahn, Kyung-Hee Kim, Jun Young Heo and Min-Kyung Yeo
Funding Agency and Grant Number	Funding Agency Grant Number Korea Health Technology R&D Project Through the Korea Health Industry Development Institute funded by the Ministry of Health & Welfare, Republic of Korea RS-2020-KH088690 National Research Foundation of Korea Grants funded by the Korean Government (MSIT) RS-2024-00406568
Corresponding Author	Min-Kyung Yeo, Associate Professor, PhD, Department of Pathology, Chungnam National University School of Medicine, Munwha-ro 266, Daejeon 35015, South Korea. mkyeo83@gmail.com
Key Words	Gallbladder cancer; Cholecystectomy; Risk factors; Time factors; Prognosis
Core Tip	This study examined temporal trends, clinicopathological features, and survival outcomes in post-cholecystectomy gallbladder cancer to identify risk factors for early detection and management. In this single-institutional study, our findings may be limited but still provide insights. Age, hypertension, cholangitis, and serological markers including total cholesterol, triglyceride, albumin were risk factors for cancer and related to survival outcomes. Pathological features, such as tumor budding, tumor size, and poorly cohesive or undifferentiated components were correlated with worse prognosis. These findings emphasize the value of early identification of high-risk profiles and the prognostic markers of gallbladder cancer.
Citation	An J, Ahn SH, Kim KH, Heo JY, Yeo MK. Twenty-year temporal trends, risk profiles, and prognostic value of clinicopathological features in gallbladder cancer following cholecystectomy. World J Gastroenterol 2025; In press

Received	2025-07-01 11:01
Peer-Review Started	2025-07-01 11:01
First Decision by Editorial Office Director	2025-08-06 11:49
Return for Revision	2025-08-06 11:49
Revised	2025-08-15 05:50
Publication Fee Transferred	2025-08-18 04:54
Second Decision by Editor	2025-12-29 02:34
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-29 09:54
Articles in Press	2025-12-29 09:54
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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