Publication Name	World Journal of Gastrointestinal Pharmacology and Therapeutics
Manuscript ID	111502
Country	United States

Category	Pharmacology & Pharmacy
Manuscript Type	Review
Article Title	Targeted nanoliposomal nutrient delivery for human health
Manuscript Source	Unsolicited Manuscript
All Author List	Joseph Mercola
Funding Agency and Grant Number
Corresponding Author	Joseph Mercola, Researcher, . drm@mercola.com
Key Words	Nanoliposomal delivery; Nutrient bioavailability; Targeted supplementation; Mitochondrial targeting; Receptor mediated endocytosis; Endosomal escape; Oral lymphatic transport; Polyethylene glycol limitations; Coenzyme Q10; Precision nutrition
Core Tip	By enclosing nutrients in nanoscale liposomes, this review shows how bioavailability leaps past gastric destruction, intestinal mucus, and first-pass metabolism while programmable surfaces steer payloads directly to kidneys, brain, or even mitochondria via ligands such as SS-31. The authors detail pH-responsive, fusogenic designs that escape endosomes, contrast natural lipid shells with immunogenic PEGylation, and map translational paths from coenzyme Q10 to heavy-metal chelation. Together, targeted nanoliposomal delivery promises drug-level precision nutrition without drug-level costs, redefining supplement science.
Citation	Mercola J. Targeted nanoliposomal nutrient delivery for human health. World J Gastrointest Pharmacol Ther 2025; In press

Received	2025-07-01 09:26
Peer-Review Started	2025-07-01 09:26
To Make the First Decision
Return for Revision	2025-07-14 07:39
Revised	2025-07-16 17:11
Second Decision	2025-10-09 02:35
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-10-10 06:44
Articles in Press	2025-10-10 06:44
Publication Fee Transferred	2025-07-17 15:51
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2150-5349 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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