Publication Name	World Journal of Clinical Oncology
Manuscript ID	111742
Country	China

Category	Oncology
Manuscript Type	Basic Study
Article Title	MiR-451a targets mex-3 RNA binding family member C to regulate human hepatoblastoma G2 cell growth and metastasis
Manuscript Source	Unsolicited Manuscript
All Author List	De-Zheng Liu, Lin Wang, Shu-Kuan Yang, Zi-Jian Zhao, Yang-Yang Cui, Xue-Kai Zhao, Fan Zhang, Qing-Hai Guan and Lei Zhou
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China No. 31640052 Natural Science Foundation of Shandong Province, China No. ZR2019BH031
Corresponding Author	Lei Zhou, Full Professor, MD, PhD, Department of Biliary-Pancreatic Surgery, Binzhou Medical University Hospital, No. 661 Huanghe 2nd Road, Binzhou 256603, Shandong Province, China. dr_zhlei@163.com
Key Words	Liver cancer; MiR-451a; Mex-3 RNA binding family member C; Proliferation; Migration
Core Tip	Aberrant microRNAs (miRNAs) expression and associated pathways have been proved participate in regulation vast various physiologic and pathologic processed of different human cancers including liver cancer. In this study, we first provided evidence that miR-451a obviously down-regulated in hepatocellular carcinoma (HCC) tissues and tumor cell lines. Overexpression of miR-451a significantly inhibit human hepatoblastoma G2 (HepG2) cell proliferation, colony formation and migration. However, miR-451a were not participated in HCC cell apoptosis. Moreover, bioinformatic analysis showed that mex-3 RNA binding family member C (MEX3C) was target gene of miR-451a, which validated by reverse transcription-polymerase chain reaction and western blotting. Furthermore, rescue experiments confirmed that overexpression of MEX3C can inhibit the effect of miR-451a in HepG2.
Citation	Liu DZ, Wang L, Yang SK, Zhao ZJ, Cui YY, Zhao XK, Zhang F, Guan QH, Zhou L. MiR-451a targets mex-3 RNA binding family member C to regulate human hepatoblastoma G2 cell growth and metastasis. World J Clin Oncol 2025; In press

Received	2025-07-09 08:31
Peer-Review Started	2025-07-09 08:37
To Make the First Decision
Return for Revision	2025-07-18 07:42
Revised	2025-07-26 14:29
Second Decision	2025-08-22 02:41
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-08-22 07:24
Articles in Press	2025-08-22 07:24
Publication Fee Transferred	2025-07-30 12:47
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ISSN	2218-4333 (online)
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