Publication Name	World Journal of Psychiatry
Manuscript ID	111807
Country	Türkiye

Category	Psychiatry
Manuscript Type	Observational Study
Article Title	Sleep quality in bipolar disorder: A comparative study of treatment with lithium and valproic acid
Manuscript Source	Invited Manuscript
All Author List	Hasan Gokcay, Uğur Takım and Tarık Sağlam
Funding Agency and Grant Number
Corresponding Author	Uğur Takım, Department of Psychiatry, University of Health Sciences, Erzurum City Hospital, Department of Psychiatry, University of Health Sciences, Erzurum City Hospital, Erzurum, Turkey. Electronic address: ugurtakim@gmail.com, Erzurum 25044, Türkiye. ugurtakim@gmail.com
Key Words	Sleep quality; Valproic acid; Bipolar disorder; Lithium; Mood stabilizers
Core Tip	This study explored how two commonly used mood stabilizers, lithium and valproic acid, affect sleep quality in patients with bipolar disorder (BD) during remission. Although overall sleep quality was poor in both groups, patients treated with lithium showed significantly better sleep efficiency and fewer sleep disturbances compared to those receiving valproic acid. These findings highlight the potential advantage of lithium in promoting more stable and restorative sleep in BD. Given the critical role of sleep in the long-term course and relapse risk of BD, our results suggest that sleep-related outcomes should be considered when selecting maintenance treatments. Further studies using objective sleep measures and longitudinal designs are needed to build on these findings.
Citation	Gokcay H, Takım U, Sağlam T. Sleep quality in bipolar disorder: A comparative study of treatment with lithium and valproic acid. World J Psychiatry 2025; In press

Received	2025-07-10 08:09
Peer-Review Started	2025-07-10 08:09
To Make the First Decision
Return for Revision	2025-07-22 03:04
Revised	2025-07-27 20:09
Second Decision	2025-08-26 02:38
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-08-26 02:59
Articles in Press	2025-08-26 02:59
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3206 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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