Publication Name	World Journal of Cardiology
Manuscript ID	111870
Country	United States

Category	Cardiac & Cardiovascular Systems
Manuscript Type	Retrospective Cohort Study
Article Title	Frailty status and outcomes of percutaneous coronary intervention in elderly patients with non-ST-elevation myocardial infarction
Manuscript Source	Invited Manuscript
All Author List	Apurva Popat, Roopeessh Vempati, Lakshmi Sai Meghana Kodali, Alla Sai Santhosha Mrudula, Fadi Haddad, Akhil Jain, Geetha Krishnamoorthy and Param Sharma
Funding Agency and Grant Number
Corresponding Author	Roopeessh Vempati, MD, Researcher, Internal Medicine, Trinity Health Oakland/Wayne State University School of Medicine, 44405 Woodward Avenue, Pontiac, MI 48341, United States. roopeessh.vempati@gmail.com
Key Words	Acute coronary syndrome; Cardiovascular outcomes; Elderly patients; Frailty; Hospital frailty risk score; In-hospital mortality; National inpatient sample; Percutaneous coronary intervention; Risk stratification
Core Tip	This study evaluates how frailty affects the outcomes of percutaneous coronary intervention (PCI) in patients aged ≥ 75 years with non-ST-elevation myocardial infarction. Using the Hospital Frailty Risk Score, we found that PCI is associated with a reduction in in-hospital mortality across all frailty categories. However, the benefits of PCI decrease as frailty increases, while complications and healthcare utilization significantly rise. These findings emphasize the need for individualized treatment strategies. While frailty should not prevent PCI, it should be considered in shared decision-making to balance the survival benefits against the procedural risks and resource demands in this high-risk population.
Citation	Popat A, Vempati R, Kodali LSM, Mrudula ASS, Haddad F, Jain A, Krishnamoorthy G, Sharma P. Frailty status and outcomes of percutaneous coronary intervention in elderly patients with non-ST-elevation myocardial infarction. World J Cardiol 2025; In press

Received	2025-07-11 05:52
Peer-Review Started	2025-07-11 05:53
To Make the First Decision
Return for Revision	2025-07-23 08:40
Revised	2025-08-06 03:44
Second Decision	2025-09-15 02:42
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-09-17 10:32
Articles in Press	2025-09-17 10:32
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1949-8462 (online)
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