Publication Name	World Journal of Gastrointestinal Pathophysiology
Manuscript ID	111957
Country	India

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Gluten’s silent strike: Unmasking its impact on liver health
Manuscript Source	Invited Manuscript
All Author List	Shivam Kalra, Simran Joshi, Manjeet K Goyal, Kartikay Goyal, Bhupender Singh, Ashita R Vuthaluru and Omesh Goyal
Funding Agency and Grant Number
Corresponding Author	Omesh Goyal, Department of Gastroenterology, Dayanand Medical College and Hospital, Tagore Nagar, Ludhiana 141001, Punjab, India. dromeshgoyal@gmail.com
Key Words	Gluten; Liver dysfunction; Gut-liver axis; Gluten-free diet; Metabolic liver disease; Autoimmune hepatitis; Transaminase elevation; Hepatic steatosis; Celiac hepatitis; Non-celiac gluten sensitivity
Core Tip	Gluten, once viewed solely as a gastrointestinal concern, is now implicated in a wide spectrum of hepatic disorders ranging from mild hypertransaminasemia to cirrhosis. Up to 40% of patients with celiac disease and 9% of those with unexplained elevated liver enzymes may have underlying gluten sensitivity. A gluten-free diet normalizes transaminase levels in most cases, yet long-term adherence may paradoxically exacerbate metabolic liver disease. This article elucidates the complex interplay between gluten, gut permeability, immune activation, and liver pathology. Recognizing gluten’s hepatic implications is crucial for early screening, tailored dietary management, and prevention of progressive liver injury in at-risk individuals.
Citation	Kalra S, Joshi S, Goyal MK, Goyal K, Singh B, Vuthaluru AR, Goyal O. Gluten’s silent strike: Unmasking its impact on liver health. World J Gastrointest Pathophysiol 2025; In press

Received	2025-07-17 03:13
Peer-Review Started	2025-07-17 03:13
To Make the First Decision
Return for Revision	2025-08-14 08:20
Revised	2025-08-18 06:30
Second Decision	2025-11-14 02:42
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-11-14 13:00
Articles in Press	2025-11-14 13:00
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2150-5330 (online)
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