Publication Name	World Journal of Clinical Pediatrics
Manuscript ID	111999
Country	India

Category	Pediatrics
Manuscript Type	Minireviews
Article Title	Role of biomarkers in pediatric sepsis: What evidence says?
Manuscript Source	Invited Manuscript
All Author List	Amit Agrawal, Dalwinder Janjua and Gaurav Jadon
Funding Agency and Grant Number
Corresponding Author	Amit Agrawal, Associate Professor, MD, Department of Pediatrics, Gandhi Medical College, Hamidia Hospital Campus, 49-B Indrapuri, B-Sector, Bhopal 462001, Madhya Pradesh, India. agrawaldramit@yahoo.co.in
Key Words	Biomarker; C-reactive protein; Interleukin-8; Serum lactate; Procalcitonin; Sepsis' septic shock; Children
Core Tip	Sepsis is common in hospitalized pediatric patients, leading to increased morbidity and mortality. Routine laboratory investigations cannot always identify the cause of diseases, and many biomarkers have been used to detect these infections. This review analyses the available evidence supporting the use of biomarkers, such as C-reactive protein, ferritin, lactate, procalcitonin, and tumor necrosis factor-alpha. The sensitivity of each marker varied in different studies, and no single biomarker can be used to identify all infections. Apart from the diagnosis, studies have assessed the role of these biomarkers in optimizing antibiotic therapy to promote early recovery.
Citation	Agrawal A, Janjua D, Jadon G. Role of biomarkers in pediatric sepsis: What evidence says? World J Clin Pediatr 2025; In press

Received	2025-07-15 09:19
Peer-Review Started	2025-07-15 09:19
To Make the First Decision
Return for Revision	2025-08-08 08:22
Revised	2025-08-27 14:55
Second Decision	2025-11-14 02:42
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-11-14 13:58
Articles in Press	2025-11-14 13:58
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ISSN	2219-2808 (online)
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