Publication Name	World Journal of Stem Cells
Manuscript ID	112207
Country	China

Category	Cell & Tissue Engineering
Manuscript Type	Basic Study
Article Title	Hypoxic preconditioned mesenchymal stem cell-derived exosomes alleviate oxidative stress-induced cardiomyocyte apoptosis through miR-486-5p
Manuscript Source	Unsolicited Manuscript
All Author List	Zi-Feng Zeng, Jin Rao, Xi-Bei Xia, Xiang-Yu Chen, Hong-Xiang He, Bin Liu, Qiong Chen, Yu-Di Liu, Guo-Ji Wang, Peng-Chao Cheng, Jun-Nan Wang, Pei Wang, Yue Yu and Zhi-Nong Wang
Funding Agency and Grant Number
Corresponding Author	Zhi-Nong Wang, PhD, Professor, Department of Cardiothoracic Surgery, Changzheng Hospital, Naval Medical University, No. 415 Fengyang Road, Huangpu District, Shanghai 200003, China. wangzn007@smmu.edu.cn
Key Words	Mesenchymal stem cells; Hypoxic preconditioning; Exosomes; miR-486-5p; Oxidative stress; Apoptosis
Core Tip	Hypoxic preconditioning enhances the therapeutic properties of mesenchymal stem cell-derived exosomes with elevated miR-486-5p, which directly inhibits phosphatase and tensin homolog to ignite phosphatidylinositol 3-kinase/protein kinase B signaling and thereby halts oxidative stress-driven cardiomyocyte apoptosis. This work uncovers a microRNA-mediated mechanism that endows exosomes with superior cardioprotective potency, offering a cell-free therapeutic strategy for oxidative-related cardiac injury.
Citation	Zeng ZF, Rao J, Xia XB, Chen XY, He HX, Liu B, Chen Q, Liu YD, Wang GJ, Cheng PC, Wang JN, Wang P, Yu Y, Wang ZN. Hypoxic preconditioned mesenchymal stem cell-derived exosomes alleviate oxidative stress-induced cardiomyocyte apoptosis through miR-486-5p. World J Stem Cells 2025; In press

Received	2025-07-22 04:06
Peer-Review Started	2025-07-22 04:06
To Make the First Decision
Return for Revision	2025-08-06 10:15
Revised	2025-08-25 08:44
Second Decision	2025-11-07 02:39
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-11-14 09:20
Articles in Press	2025-11-14 09:20
Publication Fee Transferred	2025-08-27 03:21
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-0210 (online)
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