Publication Name	World Journal of Gastroenterology
Manuscript ID	112229
Country	Malaysia

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Stem cell- and extracellular vesicle-based therapies for perianal fistulizing Crohn’s disease: An updated review
Manuscript Source	Invited Manuscript
All Author List	Payal Bhatnagar, Sherreen Elhariri, Ismail A S Burud and Nabil Eid
Funding Agency and Grant Number
Corresponding Author	Nabil Eid, Associate Professor, MD, PhD, Department of Human Biology, Anatomy Division, School of Medicine, IMU University, Bukit Jalil, Kuala Lumpur 57000, Malaysia. nabilsaleheid@imu.edu.my
Key Words	Mesenchymal stem cells; Crohn’s disease; Perianal fistulizing Crohn’s disease; Extracellular vesicles; Exosomes; Autophagy
Core Tip	Perianal fistulizing Crohn’s disease (PFCD) is a severe complication of CD, characterized by the accumulation of inflammatory cells and elevated cytokine production. Although various medical and surgical approaches aim to control this disease, recurrence remains a major challenge. Both animal models and clinical trials have shown that mesenchymal stem cells (MSCs) and their extracellular vesicles (EVs) can reduce inflammation and promote healing in refractory PFCD effects that may be further enhanced by autophagy activation. This review highlights the therapeutic potential of MSCs and their EVs in PFCD treatment and explores the supportive role of autophagy in enhancing their efficacy.
Citation	Bhatnagar P, Elhariri S, Burud IAS, Eid N. Stem cell- and extracellular vesicle-based therapies for perianal fistulizing Crohn’s disease: An updated review. World J Gastroenterol 2025; In press

Received	2025-07-22 03:37
Peer-Review Started	2025-07-22 03:37
To Make the First Decision
Return for Revision	2025-07-30 08:55
Revised	2025-08-03 09:46
Second Decision	2025-09-15 02:39
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-09-15 03:42
Articles in Press	2025-09-15 03:42
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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