Publication Name	World Journal of Orthopedics
Manuscript ID	112262
Country	Russia

Category	Orthopedics
Manuscript Type	Basic Study
Article Title	Novel use of bisphosphonates to improve surgical outcomes in experimental bone tuberculosis
Manuscript Source	Invited Manuscript
All Author List	Veronika V Petukhova, Alexander Yu Mushkin, Alexey S Maletin, Marine Z Dogonadze, Natalia V Zabolotnykh, Marina E Dyakova, Dilyara S Esmedlyaeva, Tatiana I Vinogradova and Mikhail M Kostik
Funding Agency and Grant Number	Funding Agency Grant Number Russian Science Foundation 24-15-00185
Corresponding Author	Mikhail M Kostik, MD, PhD, Professor, Hospital Pediatrics, Saint Petersburg State Pediatric Medical University, Lytovskaya 2, Saint Petersburg 194100, Russia. kost-mikhail@yandex.ru
Key Words	Tuberculosis; Bone and joint tuberculosis; Pamidronate; Bisphosphonates; Bone regeneration; Bone grafting; Bone resorption
Core Tip	A single intravenous dose of pamidronate significantly enhances bone regeneration after surgical treatment of experimental tuberculous osteitis. Pamidronate effectively inhibits early implant resorption, increases osteoblastic activity, and promotes prolonged osteogenesis, showing compatibility and safety when combined with antituberculosis therapy. This finding suggests that bisphosphonates may be a promising adjunctive therapeutic strategy for enhancing clinical outcomes in patients undergoing skeletal tuberculosis surgery.
Citation	Petukhova VV, Mushkin AY, Maletin AS, Dogonadze MZ, Zabolotnykh NV, Dyakova ME, Esmedlyaeva DS, Vinogradova TI, Kostik MM. Novel use of bisphosphonates to improve surgical outcomes in experimental bone tuberculosis. World J Orthop 2025; In press

Received	2025-07-23 05:49
Peer-Review Started	2025-07-23 05:50
To Make the First Decision
Return for Revision	2025-08-25 07:45
Revised	2025-09-04 13:29
Second Decision	2025-11-14 02:42
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-11-14 14:20
Articles in Press	2025-11-14 14:20
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ISSN	2218-5836 (online)
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