Publication Name	World Journal of Gastroenterology
Manuscript ID	112298
Country	South Korea

Category	Gastroenterology & Hepatology
Manuscript Type	Letter to the Editor
Article Title	Unraveling the gut-liver axis in autoimmune liver disease overlap syndrome: A multi-omics perspective
Manuscript Source	Unsolicited Manuscript
All Author List	Eguono D Akpoveta, Uchenna E Okpete and Haewon Byeon
Funding Agency and Grant Number	Funding Agency Grant Number Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Education No. RS-2023-00237287
Corresponding Author	Haewon Byeon, Associate Professor, Director, PhD, Worker’s Care and Digital Health Lab, Department of Future Technology, Korea University of Technology and Education, 1600, Chungjeol-ro, Cheonan 31253, Chungcheongnam-do, South Korea. bhwpuma@naver.com
Key Words	Gut microbiota; Autoimmune liver disease; Serum metabolites; Microbiome-metabolite interactions; Primary biliary cholangitis; Autoimmune hepatitis; Multi-omics analysis; Gut-liver axis
Core Tip	Autoimmune liver disease overlap syndrome, involving features of both primary biliary cholangitis and autoimmune hepatitis, poses diagnostic and therapeutic challenges due to its complex pathophysiology. This letter highlights recent evidence linking gut microbiota alterations and serum metabolite changes to liver function in affected patients. The integration of microbial and metabolic data revealed novel interaction networks that may serve as biomarkers for disease differentiation and progression.
Citation	Akpoveta ED, Okpete UE, Byeon H. Unraveling the gut-liver axis in autoimmune liver disease overlap syndrome: A multi-omics perspective. World J Gastroenterol 2025; In press

Received	2025-07-23 04:17
Peer-Review Started	2025-07-23 04:18
To Make the First Decision
Return for Revision	2025-08-14 09:37
Revised	2025-08-23 01:25
Second Decision	2025-09-04 02:48
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-09-04 03:22
Articles in Press	2025-09-04 03:22
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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