Publication Name	World Journal of Gastroenterology
Manuscript ID	112312
Country	Russia

Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	Breaking barriers in the first-line Helicobacter pylori treatment: Chinese multicenter trial validates vonoprazan-based triple therapy
Manuscript Source	Invited Manuscript
All Author List	Vasily Isakov and Alexei Goncharov
Funding Agency and Grant Number	Funding Agency Grant Number Ministry of Science and Higher Education of the Russian Federation FGMF-2025-0003
Corresponding Author	Vasily Isakov, MD, PhD, Professor, Department of Gastroenterology and Hepatology, Federal Research Center of Nutrition, Biotechnology and Food Safety, 21 Kashirskoe Shosse, Moscow 115446, Russia. vasily.isakov@gmail.com
Key Words	Helicobacter pylori; First-line treatment; Vonoprazan; Triple therapy; Proton pump inhibitors
Core Tip	This editorial highlights a pivotal multicenter randomized controlled trial from China demonstrating that vonoprazan (VPZ)-based triple therapy achieves superior or non-inferior Helicobacter pylori eradication rates compared to standard bismuth quadruple regimens, even in high clarithromycin resistance regions. The 10-day VPZ-amoxicillin-clarithromycin regimen exceeded 90% per-protocol efficacy with fewer adverse events, offering a simplified, well-tolerated alternative aligned with global treatment goals. These findings underscore a shift in empirical first-line therapy and support the integration of VPZ into updated regional and international guidelines.
Citation	Isakov V, Goncharov A. Breaking barriers in the first-line Helicobacter pylori treatment: Chinese multicenter trial validates vonoprazan-based triple therapy. World J Gastroenterol 2025; In press

Received	2025-07-23 02:03
Peer-Review Started	2025-07-23 02:04
To Make the First Decision
Return for Revision	2025-08-25 07:52
Revised	2025-08-25 14:05
Second Decision	2025-09-30 02:46
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-09-30 06:31
Articles in Press	2025-09-30 06:31
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Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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