Publication Name	World Journal of Biological Chemistry
Manuscript ID	112376
Country	India

Category	Hematology
Manuscript Type	Basic Study
Article Title	Intramuscular injection of therapeutic botulinum toxin facilitates blood coagulation in experimental aging mice
Manuscript Source	Invited Manuscript
All Author List	Sowbarnika Ravichandran, Jerly Helan Mary Joseph, Shanmugaapriya Sellathamby and Mahesh Kandasamy
Funding Agency and Grant Number	Funding Agency Grant Number The Science and Engineering Research Board No. SERB-EEQ/2016/000639 The Faculty Recharge Programme, University Grants Commission (UGC-FRP) No. F4-5 (97)/2014 Rashtriya Uchchatar Shiksha Abhiyan (RUSA) 2.0, Biological Sciences, Bharathidasan University No. TN RUSA: 311/RUSA (2.0)/2018 Human Resource Development Group No. 111-3107-4868/2K24/1 Infrastructure of the Department of Animal Science, Bharathidasan University No. UGC-SAP-DRS and No. DST-FIST CSIR-SRF Direct No. 09/0475(23353)/2025-EMR-I
Corresponding Author	Mahesh Kandasamy, Assistant Professor, Laboratory of Stem Cells and Neuroregeneration, Department of Animal Science, School of Life Sciences, Bharathidasan University, Laboratory of Stem Cells and Neuroregeneration, Department of Animal Science, School of Life Sciences, Bharathidasan University, Tiruchirappalli – 620024, Tamilnadu, India., Tiruchirappalli 620024, Tamil Nadu, India. mahesh.kandasamy@bdu.ac.in
Key Words	Coagulation; Prothrombin time; Platelet aggregation; Tail bleeding; Botulinum toxin
Core Tip	Botulinum toxin (BoNT), widely known for its therapeutic use in neurological and psychiatric disorders. It may also influence blood biochemical parameters, including hemostatic processes, as BoNT has been reported to increase platelet count, which, in turn, could play a role in regulating blood coagulation. This study demonstrates that a single mild intramuscular dose of BoNT significantly reduces bleeding time following tail transection by enhancing platelet aggregation and promoting robust fibrin clot formation. These findings highlight a novel antihemorrhagic property of BoNT, suggesting its potential application in managing bleeding complications in trauma, surgical interventions, or hemorrhagic disorders.
Citation	Ravichandran S, Joseph JHM, Sellathamby S, Kandasamy M. Intramuscular injection of therapeutic botulinum toxin facilitates blood coagulation in experimental aging mice. World J Biol Chem 2025; In press

Received	2025-07-25 01:20
Peer-Review Started	2025-07-25 01:20
To Make the First Decision
Return for Revision	2025-08-14 03:48
Revised	2025-08-27 11:22
Second Decision	2025-11-14 02:42
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-11-14 07:54
Articles in Press	2025-11-14 07:54
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ISSN	1949-8454 (online)
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