Publication Name	World Journal of Clinical Cases
Manuscript ID	112419
Country	Afghanistan

Category	Clinical Neurology
Manuscript Type	Case Report
Article Title	Silent triggers and symmetric peduncles - a rare presentation of adult-onset acute disseminated encephalomyelitis: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	Affan Faisal, Zain Tariq, Rania Usman Latif, Saim Amir, Abdul Basit and Abdul M Basil
Funding Agency and Grant Number
Corresponding Author	Abdul M Basil, MD, Department of Medicine, Spinghar Medical University, 4th Alley, Char Rahe Qambar Kabul, Kabul 1001, Kābul, Afghanistan. abdulmaboodbasil@outlook.com
Key Words	Acute disseminated encephalomyelitis; Adult-onset acute disseminated encephalomyelitis; Demyelinating disorders; Encephalopathy; Multifocal neurological deficits; Magnetic resonance imaging brain lesions; Idiopathic acute disseminated encephalomyelitis; Central nervous system inflammation; Immune-mediated encephalitis; Case report
Core Tip	Acute disseminated encephalomyelitis (ADEM) is typically a pediatric, post-infectious demyelinating disease of the central nervous system. We report a rare case of idiopathic, adult-onset ADEM in a 55-year-old man with no preceding infection, vaccination, or autoimmune history. This case underscores the diagnostic complexity of ADEM in older adults, particularly when presenting with atypical symptoms and radiological findings. Early recognition and a high index of suspicion are critical for timely intervention, even in resource-limited settings. Our findings emphasize the need to broaden diagnostic considerations for encephalopathy and multifocal neurological deficits in adults.
Citation	Faisal A, Tariq Z, Latif RU, Amir S, Basit A, Basil AM. Silent triggers and symmetric peduncles - a rare presentation of adult-onset acute disseminated encephalomyelitis: A case report. World J Clin Cases 2025; In press

Received	2025-07-27 15:08
Peer-Review Started	2025-07-27 15:08
To Make the First Decision
Return for Revision	2025-08-01 09:09
Revised	2025-08-03 16:11
Second Decision	2025-08-22 02:41
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-08-22 06:51
Articles in Press	2025-08-22 06:51
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Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2307-8960 (online)
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