Publication Name	World Journal of Cardiology
Manuscript ID	112428
Country	Russia

Category	Cardiac & Cardiovascular Systems
Manuscript Type	Editorial
Article Title	Mortality prediction in ventricular septal rupture at high altitude: A novel tool for resource-limited regions
Manuscript Source	Invited Manuscript
All Author List	Kristina G Pereverzeva
Funding Agency and Grant Number
Corresponding Author	Kristina G Pereverzeva, Associate Professor, MD, PhD, Department of Hospital Therapy with a Course in Medical and Social Expertise, Federal State Budgetary Educational Institution of Higher Education I.P. Pavlov Ryazan State Medical University of the Ministry of Health of the Russian Federation, 96 Stroykova Street, Ryazan 390026, Ryazanskaya Oblast, Russia. pereverzevakg@gmail.com
Key Words	Ventricular septal rupture; Acute myocardial infarction; High altitude; Mortality prediction; Resource-limited settings; Uric acid; Interleukin-6; Hemoglobin
Core Tip	In resource-limited high-altitude regions, ventricular septal rupture complicating myocardial infarction is associated with high mortality rates. Zhang et al developed a nomogram predicting 30-day mortality in patients with ventricular septal rupture, incorporating the following parameters: Age; Uric acid levels; Interleukin-6 and hemoglobin. The model demonstrated high predictive accuracy (area under the curve = 0.939) and enabled timely identification of candidates for emergency surgical intervention. The primary limitation for clinical implementation is the lack of routine interleukin-6 testing availability in most healthcare facilities. Multicenter validation is required prior to adoption in clinical practice.
Citation	Pereverzeva KG. Mortality prediction in ventricular septal rupture at high altitude: A novel tool for resource-limited regions. World J Cardiol 2025; In press

Received	2025-07-28 03:58
Peer-Review Started	2025-07-28 03:58
To Make the First Decision
Return for Revision	2025-07-31 08:32
Revised	2025-08-13 13:43
Second Decision	2025-09-22 02:45
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-09-22 07:04
Articles in Press	2025-09-22 07:04
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1949-8462 (online)
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