Publication Name	World Journal of Stem Cells
Manuscript ID	112434
Country	China

Category	Hematology
Manuscript Type	Letter to the Editor
Article Title	Recombinant human thrombopoietin in pediatric allogeneic hematopoietic stem cell transplantation: Clinical insights and future directions
Manuscript Source	Invited Manuscript
All Author List	Lu Cui, Jian-Chuan Deng and Nan Zhang
Funding Agency and Grant Number
Corresponding Author	Nan Zhang, Department of Hematology, The Second Affiliated Hospital of Chongqing Medical University, No. 288 Tianwen Avenue, Nan’an District, Chongqing 400010, China. zhangnan@hospital.cqmu.edu.cn
Key Words	Recombinant human thrombopoietin; Pediatric hematopoietic stem cell transplantation; Platelet engraftment; Age-dependent response; Allogeneic transplantation; Supportive care
Core Tip	This cohort study evaluates the safety and efficacy of recombinant human thrombopoietin (rhTPO) in pediatric allogeneic hematopoietic stem cell transplantation. The findings suggest that rhTPO promotes earlier platelet engraftment, particularly in younger children aged 0-9 years. This age-dependent response highlights the influence of developmental hematopoiesis on treatment outcomes. Despite the limitations of a single-center, non-randomized design, the study provides novel insights that support rhTPO as a promising supportive therapy in pediatric allogeneic hematopoietic stem cell transplantation and underscores the need for age-specific post-transplant strategies.
Citation	Cui L, Deng JC, Zhang N. Recombinant human thrombopoietin in pediatric allogeneic hematopoietic stem cell transplantation: Clinical insights and future directions. World Journal of Stem Cells 2025; In press

Received	2025-07-28 02:21
Peer-Review Started	2025-07-28 02:21
To Make the First Decision
Return for Revision	2025-09-01 08:14
Revised	2025-09-02 08:07
Second Decision	2025-09-15 02:39
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-09-15 07:54
Articles in Press	2025-09-15 07:54
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-0210 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com