Publication Name	World Journal of Methodology
Manuscript ID	112506
Country	India

Category	Anesthesiology
Manuscript Type	Observational Study
Article Title	Point-of-care ultrasound-guided saline flush test and 4-point evaluation for confirmation and malposition detection of central venous catheter tip
Manuscript Source	Invited Manuscript
All Author List	Ashutosh Kaushal, Anuj Jain, Pfokreni Lokho, Ujjwal Gupta, Rhea Thotungal, Jai Prakash Sharma, Saurabh Saigal and Sweta Kumari
Funding Agency and Grant Number
Corresponding Author	Ashutosh Kaushal, Additional Professor, DM, MD, Department of Anesthesiology and Critical Care, All India Institute of Medical Sciences, Saket Nagar, Bhopal 462026, Madhya Pradesh, India. drashutosh.kaushal@gmail.com
Key Words	Central venous catheter; Central venous catheter tip; Saline flush test; Point of care ultrasound; 4-evaluation; Malposition; Internal jugular vein; Subclavian vein
Core Tip	This prospective observational study highlights a simple, reproducible, and radiation-free method to confirm central venous catheter tip position at the bedside by combining the saline flush test with a structured four-point ultrasound evaluation. Unlike traditional chest radiography, which is delayed, resource-intensive, and exposes patients to ionizing radiation, this ultrasound protocol provides instant functional and anatomical confirmation of catheter tip placement. By offering rapid detection of malposition, minimizing complications, and streamlining clinical workflow, this approach can be readily adopted as a first-line tool in perioperative and critical care settings, especially where time-sensitive decision-making is crucial. Its simplicity also makes it feasible for clinicians with basic ultrasound training, paving the way for broader integration of point-of-care ultrasound into routine vascular access practices.
Citation	Kaushal A, Jain A, Lokho P, Gupta U, Thotungal R, Sharma JP, Saigal S, Kumari S. Point-of-care ultrasound-guided saline flush test and 4-point evaluation for confirmation and malposition detection of central venous catheter tip. World J Methodol 2025; In press

Received	2025-07-30 02:20
Peer-Review Started	2025-07-30 02:20
To Make the First Decision
Return for Revision	2025-08-19 09:17
Revised	2025-08-29 19:51
Second Decision	2025-11-14 02:42
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-11-14 13:35
Articles in Press	2025-11-14 13:35
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2222-0682 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com