Publication Name	World Journal of Clinical Oncology
Manuscript ID	112639
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Metabolic syndrome and colorectal cancer: Mechanisms, epidemiological evidence, and clinical implications
Manuscript Source	Invited Manuscript
All Author List	Fei Gao, Yan Jiao and He-Lei Wang
Funding Agency and Grant Number
Corresponding Author	He-Lei Wang, Center of General Surgery, Department of Gastrointestinal Surgery, The First Hospital of Jilin University, No. 1 Xinmin Street, Changchun 130021, Jilin Province, China. helei@jlu.edu.cn
Key Words	Metabolic syndrome; Colorectal cancer; Insulin resistance; Chronic inflammation; Abdominal obesity; Hyperglycemia
Core Tip	This comprehensive review highlights the emerging role of metabolic syndrome (MetS) as a critical modifiable risk factor in colorectal cancer (CRC) initiation, progression, and prognosis. It synthesizes mechanistic evidence involving insulin resistance, chronic inflammation, and adipokine dysregulation, and consolidates global epidemiological data linking MetS - especially abdominal obesity and hyperglycemia - to increased CRC incidence and mortality. The review also discusses the adverse impact of MetS on CRC outcomes, including recurrence and survival, and evaluates the potential of lifestyle and surgical interventions in mitigating these risks. This article underscores the importance of integrating metabolic health assessment into personalized CRC prevention and management strategies.
Citation	Gao F, Jiao Y, Wang HL. Metabolic syndrome and colorectal cancer: Mechanisms, epidemiological evidence, and clinical implications. World J Clin Oncol 2025; In press

Received	2025-08-04 00:57
Peer-Review Started	2025-08-04 00:57
To Make the First Decision
Return for Revision	2025-09-02 07:58
Revised	2025-09-04 02:02
Second Decision	2025-11-14 02:38
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-11-14 07:09
Articles in Press	2025-11-14 07:09
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2218-4333 (online)
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