Publication Name	World Journal of Diabetes
Manuscript ID	112867
Country	China

Category	Endocrinology & Metabolism
Manuscript Type	Retrospective Study
Article Title	Renal and metabolic effects of semaglutide plus canagliflozin vs canagliflozin alone in type 2 diabetic nephropathy
Manuscript Source	Unsolicited Manuscript
All Author List	Yan Miao, Pan He, Dan-Yu Wang, Lei Yan, Hui-Xia Cao and Feng-Min Shao
Funding Agency and Grant Number	Funding Agency Grant Number Major Public Welfare Projects in Henan Province 201300310700 Health Commission Project of Henan Province SBGJ202301001
Corresponding Author	Feng-Min Shao, Department of Nephrology, People's Hospital of Zhengzhou University and Henan Provincial People's Hospital, Henan Provincial Key Laboratory of Kidney Disease and Immunology, Henan Provincial Clinical Research Center for Kidney Disease, No. 7 Weiwu Road, Jinshui District, Zhengzhou 450003, Henan Province, China. shaofengmin123@163.com
Key Words	Diabetic nephropathy; Semaglutide; Canagliflozin; Combination therapy; Glucose-lipid metabolism; Renoprotection
Core Tip	This retrospective study demonstrates that, in individuals with type 2 diabetes and nephropathy, the addition of semaglutide to canagliflozin monotherapy provides better renal protection and metabolic improvements compared to canagliflozin alone. The combination significantly reduced proteinuria, improved glycemic and lipid control, enhanced β-cell function, alleviated systemic inflammation and oxidative stress, without increasing adverse events. It offers an effective and safe intensification therapy option, particularly for those who have not achieved optimal levels of proteinuria or metabolic parameters under sodium-glucose cotransporter-2 inhibitor monotherapy.
Citation	Miao Y, He P, Wang DY, Yan L, Cao HX, Shao FM. Renal and metabolic effects of semaglutide plus canagliflozin vs canagliflozin alone in type 2 diabetic nephropathy. World J Diabetes 2025; In press

Received	2025-08-26 09:23
Peer-Review Started	2025-08-27 00:45
First Decision by Editorial Office Director	2025-10-13 07:23
Return for Revision	2025-10-13 07:23
Revised	2025-10-28 08:42
Publication Fee Transferred	2025-11-03 07:58
Second Decision by Editor	2025-12-01 11:23
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-11 07:14
Articles in Press	2025-12-11 07:14
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9358 (online)
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