Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	112944
Country	Japan

Category	Oncology
Manuscript Type	Retrospective Study
Article Title	Efficacy and safety of nivolumab plus chemotherapy in patients with advanced gastric cancer with massive ascites
Manuscript Source	Unsolicited Manuscript
All Author List	Toshihiko Matsumoto, Soma Sugimoto, Reo Omori, Chinatsu Makiyama, Akio Nakasya, Hiroki Nagai, Hisateru Yasui, Reiji Higashi, Akitoshi Sasamoto and Hironaga Satake
Funding Agency and Grant Number
Corresponding Author	Toshihiko Matsumoto, Associate Chief Physician, MD, PhD, Department of Medical Oncology, Ichinomiyanishi Hospital, 1 Kaimei Aza Hira, Ichinomiya 4940001, Aichi, Japan. makoharutaro2015@gmail.com
Key Words	Gastric cancer; Ascites; Nivolumab; Chemotherapy plus nivolumab; Immune checkpoint inhibitor
Core Tip	The combination of chemotherapy and immune checkpoint inhibitors has become standard therapy for advanced gastric cancer (AGC). However, data on efficacy in patients with AGC and high ascites burden (HAB) remain limited. Chemotherapy combined with nivolumab has demonstrated modest efficacy in AGC patients with HAB (progression-free survival: 4.4 months; overall survival: 7.3 months). Chemotherapy with nivolumab improved ascites in 56% of patients. Furthermore, these results showed no correlation with programmed cell death ligand 1 (PD-L1) expression. These results suggest that nivolumab chemotherapy could be a therapeutic option for patients with AGC and HAB, regardless of PD-L1 expression.
Citation	Matsumoto T, Sugimoto S, Omori R, Makiyama C, Nakasya A, Nagai H, Yasui H, Higashi R, Sasamoto A, Satake H. Efficacy and safety of nivolumab plus chemotherapy in patients with advanced gastric cancer with massive ascites. World J Gastrointest Oncol 2025; In press

Received	2025-08-18 08:27
Peer-Review Started	2025-08-18 08:27
To Make the First Decision
Return for Revision	2025-09-04 07:14
Revised	2025-09-14 14:32
Second Decision	2025-11-19 02:37
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-11-19 08:27
Articles in Press	2025-11-19 08:27
Publication Fee Transferred	2025-09-23 09:38
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Typeset the Manuscript

ISSN	1948-5204 (online)
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