Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	112974
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Endoscopic ultrasound-guided radiofrequency ablation: A game-changer in pancreatic cancer treatment
Manuscript Source	Invited Manuscript
All Author List	Chuan Tong, Yi-Qing Hui and Jun-Rong Wang
Funding Agency and Grant Number
Corresponding Author	Jun-Rong Wang, MD, PhD, Department of Gynaecology and Obstetrics, China-Japan Union Hospital of Jilin University, No. 126 Xiantai Street, Changchun 130022, Jilin Province, China. junrongwang_2019@yeah.net
Key Words	Endoscopic ultrasound-guided radiofrequency ablation; Pancreatic cancer; Pancreatic ductal adenocarcinoma; Pancreatic neuroendocrine tumors; Immunomodulatory effects; Tumor ablation
Core Tip	Endoscopic ultrasound-guided radiofrequency ablation (EUS-RFA) is a promising minimally invasive treatment for pancreatic cancer, particularly in patients with unresectable or high-risk tumors. Recent technological advancements have improved procedural precision and safety, demonstrating high technical success rates and potential symptom palliation. When combined with chemotherapy, EUS-RFA may offer enhanced tumor control and survival benefits, though long-term clinical outcomes require further investigation. Additionally, the immunomodulatory effects of EUS-RFA may augment systemic anti-tumor immunity, offering a potential synergy with immunotherapies. However, larger randomized controlled trials and standardized protocols are needed to fully establish its role in the clinical management of pancreatic cancer.
Citation	Tong C, Hui YQ, Wang JR. Endoscopic ultrasound-guided radiofrequency ablation: A game-changer in pancreatic cancer treatment. World J Gastrointest Oncol 2026; In press

Received	2025-08-11 07:19
Peer-Review Started	2025-08-11 07:20
First Decision by Editorial Office Director	2025-11-21 09:57
Return for Revision	2025-11-24 09:01
Revised	2025-11-25 14:39
Publication Fee Transferred
Second Decision by Editor	2026-01-04 02:47
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-01-04 08:55
Articles in Press	2026-01-04 08:55
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com