Publication Name	World Journal of Transplantation
Manuscript ID	113034
Country	Colombia

Category	Medicine, Research & Experimental
Manuscript Type	Systematic Reviews
Article Title	Robotic-assisted donor and recipient hepatectomy in liver transplantation: An umbrella review of clinical outcomes, surgical performance, and cost-effectiveness
Manuscript Source	Invited Manuscript
All Author List	Carlos M Ardila, Daniel González-Arroyave and Jaime Ramírez-Arbelaez
Funding Agency and Grant Number
Corresponding Author	Carlos M Ardila, Department of Basic Sciences, Biomedical Stomatology Research Group, Faculty of Dentistry, Universidad de Antioquia, U de A, Calle 70 No. 52-21, Medellin 050010, Antioquia, Colombia. martin.ardila@udea.edu.co
Key Words	Robotic-assisted surgery; Hepatectomy; Liver transplantation; Living donor; Surgical outcomes; Cost-effectiveness; Minimally invasive surgery; Systematic review; Meta-analysis
Core Tip	This umbrella review separates donor (direct) from recipient/economic (indirect) evidence and standardizes effect reporting, heterogeneity, and grading of recommendations assessment, development and evaluation (GRADE). Donor robotics reduces blood loss and length of stay but lengthens operative time. Recipient robotics shows fewer conversions to open intervention and lower severe morbidity, with no mortality difference. Economic contrasts are context-dependent, with higher procedural but lower hospitalization costs for robotic vs. open, and laparoscopy the least expensive overall. The Preferred Reporting Items for Systematic reviews and Meta-Analyses counts, citation-matrix/corrected covered area, AMSTAR 2, and outcome-level GRADE profiles are provided to ensure an audit-ready package and to map evidence gaps that future transplant-specific studies must address.
Citation	Ardila CM, González-Arroyave D, Ramírez-Arbelaez J. Robotic-assisted donor and recipient hepatectomy in liver transplantation: An umbrella review of clinical outcomes, surgical performance, and cost-effectiveness. World J Transplant 2025; In press

Received	2025-08-13 03:33
Peer-Review Started	2025-08-13 03:34
To Make the First Decision
Return for Revision	2025-09-12 06:58
Revised	2025-09-18 21:24
Second Decision	2025-11-25 02:44
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-11-26 06:17
Articles in Press	2025-11-26 06:17
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Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3230 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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