Publication Name	World Journal of Psychiatry
Manuscript ID	113104
Country	China

Category	Psychiatry
Manuscript Type	Retrospective Study
Article Title	Risk factors and early identification markers for post-ischemic stroke anxiety and depression
Manuscript Source	Unsolicited Manuscript
All Author List	Jie-Dong Zhao, Song-Wang Qiu, Kai-Yan Lin, Hui-Yan Lin and Chang-Wei Yu
Funding Agency and Grant Number
Corresponding Author	Chang-Wei Yu, Department of Neurology, The First Affiliated Hospital of Xiamen University, No. 160 Hexiang West Road, Siming District, Xiamen 361000, Fujian Province, China. 15880284048@163.com
Key Words	Ischemic stroke; Anxiety and depression; Risk factors; Biomarkers; Brain-derived neurotrophic factor
Core Tip	Post-stroke anxiety and depression are common yet underrecognized complications after ischemic stroke, adversely affecting recovery and prognosis. This study integrates demographic, clinical, neuroimaging, inflammatory, and neuroendocrine indicators to identify independent risk factors and early biomarkers for post-stroke anxiety and depression. Female gender, prior mental disorders, frontal-limbic infarcts, severe stroke, and low social support were key predictors. Elevated interleukin-6, tumor necrosis factor-alpha, and cortisol, alongside reduced insulin-like growth factor-1, showed strong diagnostic value, providing a multidimensional framework for early screening and targeted intervention in high-risk patients.
Citation	Zhao JD, Qiu SW, Lin KY, Lin HY, Yu CW. Risk factors and early identification markers for post-ischemic stroke anxiety and depression. World J Psychiatry 2025; In press

Received	2025-09-16 09:28
Peer-Review Started	2025-09-16 09:28
First Decision by Editorial Office Director	2025-10-11 02:50
Return for Revision	2025-10-11 02:50
Revised	2025-10-21 14:51
Publication Fee Transferred	2025-10-23 03:53
Second Decision by Editor	2025-12-03 02:40
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-03 08:38
Articles in Press	2025-12-03 08:38
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3206 (online)
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