Publication Name	World Journal of Gastroenterology
Manuscript ID	113232
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Meta-Analysis
Article Title	Efficacy of indomethacin for the prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis: A comprehensive meta-analysis of randomized controlled trials
Manuscript Source	Unsolicited Manuscript
All Author List	Fu Tian, Zhi-Cheng Huang, Hayat Khizar and Kai Qiu
Funding Agency and Grant Number
Corresponding Author	Kai Qiu, MD, Department of Intensive Care Unit, Hangzhou Geriatric Hospital, 50 Jingshen Road, ,, Hangzhou 310022, Zhejiang Province, China. 1007743527@qq.com
Key Words	Post-endoscopic retrograde cholangiopancreatography pancreatitis; Indomethacin; Pancreatitis prevention; Prophylaxis; Meta-analysis
Core Tip	This meta-analysis assessed the efficacy of rectal indomethacin in the prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis by reviewing the results of 30 randomized controlled trials. Indomethacin didn’t show a significant reduction in overall post-endoscopic retrograde cholangiopancreatography pancreatitis rates or adverse events relative to controls, however, it may be beneficial in particular high-risk patients, but with caution given to significant heterogeneity in the results.
Citation	Tian F, Huang ZC, Khizar H, Qiu K. Efficacy of indomethacin for the prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis: A comprehensive meta-analysis of randomized controlled trials. World J Gastroenterol 2025; In press

Received	2025-08-19 04:13
Peer-Review Started	2025-08-19 04:13
To Make the First Decision
Return for Revision	2025-08-28 10:15
Revised	2025-09-03 07:01
Second Decision	2025-09-30 02:46
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-09-30 04:03
Articles in Press	2025-09-30 04:03
Publication Fee Transferred	2025-09-04 08:07
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com