Publication Name	World Journal of Methodology
Manuscript ID	113265
Country	Pakistan

Category	Hematology
Manuscript Type	Systematic Reviews
Article Title	Comparative effectiveness of parenteral anticoagulants (fondaparinux, argatroban, bivalirudin) in heparin-induced thrombocytopenia: A systematic review
Manuscript Source	Invited Manuscript
All Author List	Abdul Rehman, Mehsim Abid, Hira Jamil, Sadia Siddique, Sagar Parkash, FNU Nasrullah, FNU Sapna, Bhawna Lohana, Kiran Lohana, Inshal Jawed, Mohammad Tufail and Mohammad Sarim Sharaf
Funding Agency and Grant Number
Corresponding Author	Inshal Jawed, Chief Physician, Senior Researcher, Department of Medicine, Dow University of Health Sciences, Baba-e-urdu Karachi, Karachi 75350, Sindh, Pakistan. inshaljwd@gmail.com
Key Words	Heparin-induced thrombocytopenia; Fondaparinux; Argatroban; Bivalirudin; Anticoagulation; Systematic review
Core Tip	Heparin-induced thrombocytopenia is life-threatening and needs alternative anticoagulation. The systematic review included sixteen studies on 2867 patients treated with fondaparinux, bivalirudin and argatroban. None of these agents proved superior, and evidence certainty was low to very low, mainly because most studies were observational and showed heterogeneity. All three agents demonstrated acceptable efficacy and safety; however, treatment choice should be patient specific and clinically informed. Randomized trials are urgently needed to support evidence-based treatment decisions.
Citation	Rehman A, Abid M, Jamil H, Siddique S, Parkash S, Nasrullah F, Sapna F, Lohana B, Lohana K, Jawed I, Tufail M, Sharaf MS. Comparative effectiveness of parenteral anticoagulants (fondaparinux, argatroban, bivalirudin) in heparin-induced thrombocytopenia: A systematic review. World J Methodol 2025; In press

Received	2025-08-20 04:53
Peer-Review Started	2025-08-20 04:53
First Decision by Editorial Office Director	2025-09-12 06:45
Return for Revision	2025-09-12 06:45
Revised	2025-09-21 19:37
Publication Fee Transferred
Second Decision by Editor	2025-12-30 02:36
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-30 10:31
Articles in Press	2025-12-30 10:31
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2222-0682 (online)
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