Publication Name	World Journal of Orthopedics
Manuscript ID	113405
Country	China

Category	Orthopedics
Manuscript Type	Minireviews
Article Title	Lipid metabolism disorders and osteoarthritis progression: Potential intervention with plant active ingredients
Manuscript Source	Invited Manuscript
All Author List	Tao Zhang, Jin-Long Liu, Wei Wang, Ke Ren, Xiao-Mei Liu, Ke Cao, Zhen Li, Xi-Yao Cheng, Xin-Yu Zhang and Wen-Sheng Xu
Funding Agency and Grant Number	Funding Agency Grant Number Natural Science Foundation of Inner Mongolia Autonomous Region Project 2022MS08039 Lucheng Talent Program of Baotou, Inner Mongolia Autonomous Region (China) YFYRC-LCYC-2023002 2025 College Students’ Innovation and Entrepreneurship Training Program Project 202510130001 Graduate Education and Teaching Reform Project in Inner Mongolia Autonomous Region JG2024006Z
Corresponding Author	Wen-Sheng Xu, Chief Physician, Deputy Director, Professor, Senior Researcher, The First Affiliated Hospital, Baotou Medical College, No. 41 Linyin Road, Kundulun District, Baotou 014000, Inner Mongolia Autonomous Region, China. xwsoye@126.com
Key Words	Osteoarthritis; Adipose tissue; Lipid metabolism; Lipid metabolism disorders; Plant active ingredients
Core Tip	This review summarizes the relationship between lipid metabolism disorders and osteoarthritis (OA), highlights the mechanisms by which representative phytochemicals (e.g., curcumin, green tea polyphenols, resveratrol) regulate lipid metabolism and attenuate OA progression, and further analyzes the endocrine role of adipose tissue, the impact of fatty acid metabolism on OA, and the therapeutic potential of phytochemicals through lipid metabolism modulation.
Citation	Zhang T, Liu JL, Wang W, Ren K, Liu XM, Cao K, Li Z, Cheng XY, Zhang XY, Xu WS. Lipid metabolism disorders and osteoarthritis progression: Potential intervention with plant active ingredients. World J Orthop 2025; In press

Received	2025-08-25 03:13
Peer-Review Started	2025-08-25 03:13
First Decision by Editorial Office Director	2025-09-12 06:49
Return for Revision	2025-09-12 06:49
Revised	2025-09-21 16:52
Publication Fee Transferred
Second Decision by Editor	2025-12-04 02:35
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-04 07:32
Articles in Press	2025-12-04 07:32
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2218-5836 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com