Publication Name	World Journal of Cardiology
Manuscript ID	113443
Country	Italy

Category	Cardiac & Cardiovascular Systems
Manuscript Type	Editorial
Article Title	Reimagining risk stratification: Dipeptidyl peptidase 3 in the new era of cardiovascular biomarkers
Manuscript Source	Invited Manuscript
All Author List	Davide Ramoni, Luca Liberale, Federico Carbone and Fabrizio Montecucco
Funding Agency and Grant Number
Corresponding Author	Fabrizio Montecucco, MD, PhD, Professor, Department of Internal Medicine, University of Genoa, Viale Benedetto XV 6, Genoa 16132, Italy. fabrizio.montecucco@unige.it
Key Words	Acute coronary syndrome; Cardiogenic shock; Dipeptidyl peptidase 3; Heart failure; Inflammation; Prognostic biomarkers; Renin–angiotensin–aldosterone system; Risk stratification; Therapeutic targeting
Core Tip	Dipeptidyl peptidase 3 (DPP3) is a novel biomarker and active mediator in cardiovascular disease. Unlike traditional markers that simply reflect tissue injury, circulating DPP3 (cDPP3) directly influences hemodynamics by degrading angiotensin II and other vasoactive peptides, contributing to vasodilation, myocardial depression, and shock progression. Elevated cDPP3 predicts cardiogenic shock and mortality in acute coronary syndromes and heart failure, while its dynamic trajectory provides unique prognostic value. Beyond risk stratification, therapeutic neutralization of cDPP3 shows promise in reversing circulatory failure, positioning it at the interface of biomarker discovery and targeted intervention.
Citation	Ramoni D, Liberale L, Carbone F, Montecucco F. Reimagining risk stratification: Dipeptidyl peptidase 3 in the new era of cardiovascular biomarkers. World J Cardiol 2025; In press

Received	2025-08-26 02:12
Peer-Review Started	2025-08-26 02:12
To Make the First Decision
Return for Revision	2025-09-09 09:53
Revised	2025-09-18 15:19
Second Decision	2025-11-25 02:38
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-11-25 13:01
Articles in Press	2025-11-25 13:01
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1949-8462 (online)
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